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The Journal of Immunology (100 unread)

 
  • Permalink for 'Alternaria B Cell Mimotope Immunotherapy Alleviates Allergic Responses in a Mouse Model [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    Alternaria B Cell Mimotope Immunotherapy Alleviates Allergic Responses in a Mouse Model [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • We screened Alternaria B cell epitopes by the combination of s-IgE and phage.

  • We validated the binding ability of B cell mimotopes in humans and mice in vitro.

  • The B cell mimotope vaccines improved allergic inflammation in a mouse model.

  • Permalink for 'HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Intracellular HB-EGF expressed by CD4 T cells increases IL-5 expression by TH2 cells.

  • HB-EGF in CD4 T cells regulates IL-5 synthesis by inhibiting Bcl-6.

  • Permalink for 'Nanoparticles Containing an Insulin-ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells [AUTOIMMUNITY]' 22:00

    Nanoparticles Containing an Insulin-ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • A hybrid insulin peptide (HIP) neoepitope can tolerize diabetogenic T cells.

  • Tolerance induction promotes T cell anergy and increases Treg/Teff ratio.

  • HIPs are potential therapeutics in type 1 diabetes.

  • Permalink for 'Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus [AUTOIMMUNITY]' 22:00

    Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CD40 antagonism reverses severe proteinuria and restores glomerular morphology.

  • CD40 antagonism normalizes nephrotic and injury-associated gene expression.

  • CD40 antagonism disrupts multiple disease-critical immunological mechanisms.

  • Permalink for 'A Deficit of CEACAM-1-Expressing T Lymphocytes Supports Inflammation in Primary Progressive Multiple Sclerosis [AUTOIMMUNITY]' 22:00

    A Deficit of CEACAM-1-Expressing T Lymphocytes Supports Inflammation in Primary Progressive Multiple Sclerosis [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CEACAM-1/TIM-3 interaction favors the apoptosis of MBP-specific cells in BEMS.

  • This pathway is reduced in PPMS by the upregulation of Bat3.

  • Permalink for 'Widespread Tau-Specific CD4 T Cell Reactivity in the General Population [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Widespread Tau-Specific CD4 T Cell Reactivity in the General Population [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • PP2A readily promotes IL-2R signaling in Tregs but not T effector cells.

  • PP2A enhances IL-2R signaling in Tregs by CD25-dependent and -independent mechanisms.

  • PP2A broadly regulates the stability, activation, and function of human Tregs.

  • Permalink for 'Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism [IMMUNE REGULATION]' 22:00

    Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • PAR1 is transiently expressed in osteoclast precursor cells during differentiation.

  • PAR1 deletion enhances osteoclastogenesis, whereas PAR1 overexpression inhibits it.

  • The enhanced osteoclastogenesis of PAR1-deletion is mediated by Notch2.

  • Permalink for 'The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection [IMMUNE REGULATION]' 22:00

    The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • MFSD2A is required for CD8+ memory T cell maintenance.

  • MFSD2A deficiency results in defective import of LPC species into CD8+ T cells.

  • Import of LPC helps to maintain memory T cell homeostasis.

  • Permalink for 'Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis [IMMUNE REGULATION]' 22:00

    Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Metformin enhances immunomodulatory properties and migration capacity of MSCs.

  • Metformin-treated MSCs exert therapeutic property in OA rats.

  • Permalink for 'Effects of PI3K Inhibition on Afucosylated Antibody-Driven Fc{gamma}RIIIa Events and Phospho-S6 Activity in NK Cells [IMMUNE REGULATION]' 22:00

    Effects of PI3K Inhibition on Afucosylated Antibody-Driven Fc{gamma}RIIIa Events and Phospho-S6 Activity in NK Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Afucosylated Abs offset PI3K inhibitors to retain effective signaling and function.

  • Phosphorylation of S6 is temporally driven by PI3K.

  • p-S6 temporally regulates late cytokine production by modulating transcription.

  • Permalink for 'The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function [IMMUNE REGULATION]' 22:00

    The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • The miR-511-3p regulates MR and DC-SIGN expression in human DCs.

  • Silencing miR-511-3p expression promotes anti-inflammatory DC phenotype.

  • Changes in miR-511-3p levels in DCs affect T cell polarization in DC–T coculture.

  • Permalink for 'Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes [IMMUNE REGULATION]' 22:00

    Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • NOD mice are deficient in number and function of CD8 Tregs that control the germinal center.

  • Treatment with IL-15 superagonist expands NOD CD8 Tregs and restores their activity.

  • IL-15–activated CD8 Tregs delay the adoptive transfer of type 1 diabetes.

  • Permalink for 'Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • BMDNT cells are developed by default of thymic TCR-mediated selection.

  • BMDNT cells show the features of ILCs bearing many NK receptors.

  • BMDNT cells are rapidly increased and activated in response to systemic TLR ligands.

  • Permalink for 'Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Radiation induces S2053 phosphorylation of murine DNA-PKcs.

  • S2053 phosphorylation is dispensable for V(D)J and class switch recombination.

  • Permalink for 'SOCS1 Antagonist-Expressing Recombinant Bacillus Calmette-Guerin Enhances Antituberculosis Protection in a Mouse Model [IMMUNOTHERAPY AND VACCINES]' 22:00

    SOCS1 Antagonist-Expressing Recombinant Bacillus Calmette-Guerin Enhances Antituberculosis Protection in a Mouse Model [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • rBCG-SOCS1DN enhanced the induction of Ag-specific T cells via the activation of DC.

  • Ag-specific T cell enhancement enhanced protection against M. tuberculosis infection.

  • Permalink for 'Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma [IMMUNOTHERAPY AND VACCINES]' 22:00

    Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Inducibly expressed IL-12–armored GPC3-specific CARs were constructed in this study.

  • GPC3-28Z-NFAT-IL-12 T cells could lyse GPC3+ tumor cells specifically in vitro.

  • GPC3-28Z-NFAT-IL-12 T cells could enhance antitumor activity in vivo.

  • Permalink for 'T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Gastric PC acquire high rates of somatic hypermutations during H. pylori infection.

  • Gastric poly- and H. pylori–specific Ig evolve from Ag-driven and T cell–dependent responses.

  • VH genes of H. pylori–specific Ig resemble MALT B cell lymphoma Ig genes.

  • Permalink for 'Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Carp macrophages exhibit a trained immunity-like profile in vitro.

  • Both peptidoglycan and β-glucan can induce trained immunity in carp macrophages.

  • Permalink for 'C-Reactive Protein Promotes Inflammation through Fc{gamma}R-Induced Glycolytic Reprogramming of Human Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    C-Reactive Protein Promotes Inflammation through Fc{gamma}R-Induced Glycolytic Reprogramming of Human Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Under inflammatory conditions, CRP is not only a marker but also a driver of inflammation by human macrophages.

  • CRP enhances inflammatory cytokine production via FcR-induced metabolic reprogramming through kinases Syk, PI3K, and AKT2.

  • Permalink for 'Inflammasome-Independent and Atypical Processing of IL-1{beta} Contributes to Acid Aspiration-Induced Acute Lung Injury [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Inflammasome-Independent and Atypical Processing of IL-1{beta} Contributes to Acid Aspiration-Induced Acute Lung Injury [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Inflammasome-independent IL-1β production contributes to aspiration pneumonitis.

  • Acidic stress induces the production of mature IL-1β in macrophages.

  • A novel cleavage site of IL-1β in response to acidic stress was identified.

  • Permalink for 'Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Lung endothelial precursor cells are committed to EndoMT during experimental fibrosis.

  • Signals in the sera of patients with systemic sclerosis reproduce EndoMT in vitro.

  • Macrophages protect from both EndoMT induction and experimental fibrosis.

  • Permalink for 'USP19 Inhibits TNF-{alpha}- and IL-1{beta}-Triggered NF-{kappa}B Activation by Deubiquitinating TAK1 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    USP19 Inhibits TNF-{alpha}- and IL-1{beta}-Triggered NF-{kappa}B Activation by Deubiquitinating TAK1 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • USP19 negatively regulates TAK1-mediated NF-B activation.

  • Usp19 deficiency promotes TNF-α– and IL-1β–induced inflammatory response.

  • USP19 removes K63- and K27-linked polyubiquitin chains from TAK1.

  • Permalink for 'CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CUL7-FBXW11 E3 ligase mediates the ubiquitination and degradation of AID.

  • DNA damage response promotes CUL7–FBXW11–AID interaction.

  • Knockout of CUL7 promotes IgA and IgG1 class switch recombination of B cells.

  • Permalink for 'Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43 [MUCOSAL IMMUNOLOGY]' 22:00

    Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43 [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Depletion of gut microbiota decreases the adjuvant activity of CT.

  • Gut microbiota-derived SCFAs facilitate mucosal adjuvant activity of CT via GPR43.

  • SCFA induction of BAFF and ALDH1a2 in DC promotes B cell Ab production.

  • Permalink for 'Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses [CORRECTIONS]' 22:00

    Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses [CORRECTIONS]

     » ‎ The Journal of Immunology
  • June 03, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity [BRIEF REVIEWS]' 22:00

    The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Identification and Structure of an MHC Class I-Encoded Protein with the Potential to Present N-Myristoylated 4-mer Peptides to T Cells [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • The rhesus MHC class I allele, Mamu-B*05104, presents 4-mer lipopeptides to CTLs.

  • Its large, hydrophobic B pocket accommodates the acylated glycine as an anchor.

  • The T cell epitopic diversity appears to be limited for lipopeptides.

  • Permalink for 'Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4-IFN-{beta} Axis [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4-IFN-{beta} Axis [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Hp inhibits osteoclastogenesis via the TLR4–IFN-β axis.

  • Hp acts as a ligand for TLR4.

  • Hp promotes IFN-β expression through TLR4.

  • Permalink for 'Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Influenza A Virus Infection Induces Viral and Cellular Defective Ribosomal Products Encoded by Alternative Reading Frames [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • We identified an ARF epitope NS1-ARF21–8, encoded by NS1 mRNA of influenza A virus.

  • NS1-ARF21–8 elicits robust immunodominant TCD8+ response in infected BALB/c mice.

  • NS1-ARF21–8 precursor (14-residue peptide) has no detectable biological function.

  • Permalink for 'A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation [AUTOIMMUNITY]' 22:00

    A Precision B Cell-Targeted Therapeutic Approach to Autoimmunity Caused by Phosphatidylinositol 3-Kinase Pathway Dysregulation [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Low-dosage p110 inhibitor therapy prevents PTEN- but not SHP-1–driven autoimmunity.

  • Effective p110 inhibitor dosages spare immune responses to exogenous immunogens.

  • Low-dosage p110 inhibitor therapy delays T1D progression in VH125.NOD mice.

  • Permalink for 'Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Targeted Delivery of Curcumin Rescues Endoplasmic Reticulum-Retained Mutant NOX2 Protein and Avoids Leukocyte Apoptosis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • MAIT cells require glycolytic metabolism for their cytokine production.

  • MAIT cell glycolysis is regulated by mTORC1 and SLC7A5.

  • MAIT cells display defective glycolytic metabolism in obese adults.

  • Permalink for 'Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys [IMMUNE REGULATION]' 22:00

    Low-Dose Maraviroc, an Antiretroviral Drug, Attenuates the Infiltration of T Cells into the Central Nervous System and Protects the Nigrostriatum in Hemiparkinsonian Monkeys [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Loss of glia limitans and infiltration of T cells in the SN is evident in a monkey model of PD.

  • Oral maraviroc protected the endothelial monolayer and reduced T cell infiltration.

  • Oral maraviroc protected the nigrostriatum and improved locomotor activities.

  • Permalink for 'SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    SSB1/SSB2 Proteins Safeguard B Cell Development by Protecting the Genomes of B Cell Precursors [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Combined deficiency of Ssb1 and Ssb2 abrogates early B cell development.

  • SSB1/2 depletion causes defects in proliferation, genome fragility, and apoptosis.

  • Mature B cells largely tolerate SSB1/2 loss.

  • Permalink for 'ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing {beta}-Selection [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    ISWI ATPase Smarca5 Regulates Differentiation of Thymocytes Undergoing {beta}-Selection [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • ISWI ATPase Smarca5 guides developmental mRNA program of β-selected thymocytes.

  • Inactivation of Smarca5 gene in developing thymocytes activates p53 and apoptosis.

  • Smarca5 regulates cell fate decisions of thymocytes and survival of pro-B cells.

  • Permalink for 'In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis [IMMUNOTHERAPY AND VACCINES]' 22:00

    In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • DCs engineered to overexpress 1,25(OH)2D and RA augment gut-homing Treg cell induction.

  • Transfer of the engineered DCs robustly suppresses ongoing experimental colitis.

  • The engineered DCs require Foxp3+ Treg cells to maximally suppress experimental colitis.

  • Permalink for 'Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer [IMMUNOTHERAPY AND VACCINES]' 22:00

    Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • TILs can be grown from primary bladder tumors.

  • Neoantigen-reactive TILs can be isolated from a bladder tumor specimen.

  • Permalink for 'Gasdermin D Protects from Melioidosis through Pyroptosis and Direct Killing of Bacteria [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Gasdermin D Protects from Melioidosis through Pyroptosis and Direct Killing of Bacteria [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • GSDMD-deficient mice are more susceptible to melioidosis.

  • In vivo production of IL-1β by neutrophils is independent of GSDMD.

  • GSDMD and pyroptosis are directly microbicidal.

  • Permalink for 'Prostaglandin E2 Inhibits the Ability of Neutrophils to Kill Listeria monocytogenes [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Prostaglandin E2 Inhibits the Ability of Neutrophils to Kill Listeria monocytogenes [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • PGE2 treatment reduces the ability of PMN to kill Listeria monocytogenes.

  • Cells from the livers of infected BALB mice produced more PGE2 than those from C57BL/6 mice.

  • Permalink for 'SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Murine SIDT1 colocalizes with late endolysosomes and interacts with long dsRNA [poly(I:C)] but not siRNA or dsDNA.

  • SIDT1 expression is induced following type I IFN and poly(I:C) stimulation.

  • Loss of SIDT1 impairs IFNβ production following infection with HSV-1 but does not affect overall survival.

  • Permalink for 'Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The bat MHC I exhibits distinctive structural characteristics.

  • Significant differences exist in the peptidome between inside the cell and outside the cell.

  • A cluster of uniquely inserted residues may help promote high-affinity peptide binding.

  • Permalink for 'Healthy Donors Exhibit a CD4 T Cell Repertoire Specific to the Immunogenic Human Hormone H2-Relaxin before Injection [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Healthy Donors Exhibit a CD4 T Cell Repertoire Specific to the Immunogenic Human Hormone H2-Relaxin before Injection [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • H2-relaxin–specific T cells are detected in the blood of healthy donors.

  • T cell response to H2-relaxin relies on several CD4 T cell epitopes.

  • An H2-relaxin–specific T cell repertoire might account for its clinical immunogenicity.

  • Permalink for 'IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils [TRANSPLANTATION]' 22:00

    IL-3 Triggers Chronic Rejection of Cardiac Allografts by Activation of Infiltrating Basophils [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • IL-3 induces allograft fibrosis and chronic rejection of heart transplants.

  • IL-3 exerts profibrotic effects by activation of infiltrating basophils.

  • IL-6 is an important basophil-derived mediator of fibrosis.

  • Permalink for 'Antigen Priming with Enantiospecific Cationic Lipid Nanoparticles Induces Potent Antitumor CTL Responses through Novel Induction of a Type I IFN Response [TUMOR IMMUNOLOGY]' 22:00

    Antigen Priming with Enantiospecific Cationic Lipid Nanoparticles Induces Potent Antitumor CTL Responses through Novel Induction of a Type I IFN Response [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • A single delivery of R-DOTAP plus peptide Ag induces regression of large tumors.

  • R-DOTAP possesses intrinsic immunostimulatory activity mediated by type I IFN.

  • R-DOTAP activity requires Myd88 but not STING or TRIF, and it activates TLR7 and 9.

  • May 20, 2019
  • Permalink for 'Fifty Years (Well, Almost!) in Immunology [PRESIDENT'S ADDRESS]' 22:00

    Fifty Years (Well, Almost!) in Immunology [PRESIDENT'S ADDRESS]

     » ‎ The Journal of Immunology
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'Mystery Solved: IL-15 [PILLARS OF IMMUNOLOGY]' 22:00

    Mystery Solved: IL-15 [PILLARS OF IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality [BRIEF REVIEWS]' 22:00

    Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: ATM Influences Germinal Center Integrity [CUTTING EDGE]' 22:00

    Cutting Edge: ATM Influences Germinal Center Integrity [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Loss of ATM leads to apoptosis of germinal center B cells.

  • Deletion of ATM in B cells reduces germinal center frequency and size.

  • ATM loss leads to decreased titers of class-switched Abs after immunization.

  • Permalink for 'Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts [AUTOIMMUNITY]' 22:00

    Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Citrullination is the key event for DC transdifferentiation into OCs.

  • ACPA binding to DCs can induce bone loss.

  • Permalink for 'TNF and IL-1 Play Essential but Temporally Distinct Roles in Driving Cardiac Inflammation in a Murine Model of Kawasaki Disease [AUTOIMMUNITY]' 22:00

    TNF and IL-1 Play Essential but Temporally Distinct Roles in Driving Cardiac Inflammation in a Murine Model of Kawasaki Disease [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Permalink for 'Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation [AUTOIMMUNITY]' 22:00

    Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Permalink for 'A New IRF-1-Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection [IMMUNE REGULATION]' 22:00

    A New IRF-1-Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity [IMMUNE REGULATION]' 22:00

    Dlg1 Maintains Dendritic Cell Function by Securing Voltage-Gated K+ Channel Integrity [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Dlg1-deficient DCs possess a lower capacity to mediate Ab responses.

  • Dlg1 deficiency in DCs impairs Ag update and cytokine production.

  • Dlg1 modulates DC activation and function through voltage-gated K+ channels.

  • Permalink for 'Runx1 and ROR{gamma}t Cooperate to Upregulate IL-22 Expression in Th Cells through Its Distal Enhancer [IMMUNE REGULATION]' 22:00

    Runx1 and ROR{gamma}t Cooperate to Upregulate IL-22 Expression in Th Cells through Its Distal Enhancer [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • CNS-32 is a distal enhancer element to upregulate Il22 expression.

  • CNS-32 interacts with the Il22 promoter via chromatin looping.

  • Runx1 and RORt cooperatively upregulate Il22 expression through binding to CNS-32.

  • Permalink for 'Critical Role for TCR Signal Strength and MHC Specificity in ThPOK-Induced CD4 Helper Lineage Choice [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Critical Role for TCR Signal Strength and MHC Specificity in ThPOK-Induced CD4 Helper Lineage Choice [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Differential ThPOK levels are required for suppression of cytotoxicity and activation of helper program.

  • TCR specificity and signal strength modulate ThPOK-induced CD4 helper lineage choice.

  • Permalink for 'Measuring Thymic Clonal Deletion at the Population Level [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Measuring Thymic Clonal Deletion at the Population Level [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Cleaved caspase 3 with activation analysis identifies deleted T cells in the thymus.

  • CD28-mediated costimulation is critical to medullary and cortical clonal deletion.

  • Permalink for 'Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice [IMMUNOTHERAPY AND VACCINES]' 22:00

    Vaccination with a Single-Cycle Respiratory Syncytial Virus Is Immunogenic and Protective in Mice [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • The live-attenuated, single-cycle RSV M-null vaccine is significantly attenuated.

  • RSV M-null vaccination in mice induces robust acute and memory immune responses.

  • Vaccination with RSV M-null provides protection against secondary viral challenge.

  • Permalink for 'A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    A Requirement for Neutrophil Glycosaminoglycans in Chemokine:Receptor Interactions Is Revealed by the Streptococcal Protease SpyCEP [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • SpyCEP-cleaved CXCL8 is unable to bind and activate CXCL8 receptors.

  • Neutrophil glycosaminoglycans are required for migration along a CXCL8 gradient.

  • Permalink for 'Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Tetraspanin CD82 Organizes Dectin-1 into Signaling Domains to Mediate Cellular Responses to Candida albicans [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Dectin-1 clustering via CD82 enables robust downstream Dectin-1 signaling.

  • Lack of CD82 reduces macrophage fungal killing and survival of Candida infection.

  • CD82 SNPs modulate cytokine production or risk of Candida infections.

  • Permalink for 'Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Tissue Inhibitor of Metalloproteinase-1 Promotes Polymorphonuclear Neutrophil (PMN) Pericellular Proteolysis by Anchoring Matrix Metalloproteinase-8 and -9 to PMN Surfaces [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • TIMP-1 is rapidly expressed on PMN surfaces when PMNs are activated.

  • Surface-bound TIMP-1 serves as the receptor for MMP-8 and -9 on PMNs.

  • Surface-bound TIMP-1 promotes (rather than inhibits) PMN pericellular proteolysis.

  • Permalink for 'The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Lyve and Ccr2 identify embryonic and BM-derived cardiac macrophages, respectively.

  • Ccr2pos macrophages numerically increase during inflammation.

  • Ccr2pos macrophages accumulate around the major vessels and trigger vasculitis.

  • Permalink for 'Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Twist1 and Twist2 Induce Human Macrophage Memory upon Chronic Innate Receptor Treatment by HDAC-Mediated Deacetylation of Cytokine Promoters [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Twist1 and Twist2 promote HDAC1 and HDAC3 upregulation with chronic PRR stimulation.

  • HDAC1/HDAC3 bind to and deacetylate cytokine promoters with chronic PRR stimulation.

  • HDAC1 and HDAC3 reduce cytokines after prolonged microbial ligand exposure.

  • Permalink for 'Genomic Identification of Low-Density Granulocytes and Analysis of Their Role in the Pathogenesis of Systemic Lupus Erythematosus [SYSTEMS IMMUNOLOGY]' 22:00

    Genomic Identification of Low-Density Granulocytes and Analysis of Their Role in the Pathogenesis of Systemic Lupus Erythematosus [SYSTEMS IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • A module of genes defining LDGs in lupus has been identified.

  • LDG gene enrichment correlates with corticosteroid use, anti-dsDNA, and low complement.

  • LDGs were not detected in lupus-affected tissues.

  • Permalink for 'Local Attachment Explains Small World-like Properties of Fibroblastic Reticular Cell Networks in Lymph Nodes [SYSTEMS IMMUNOLOGY]' 22:00

    Local Attachment Explains Small World-like Properties of Fibroblastic Reticular Cell Networks in Lymph Nodes [SYSTEMS IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • FRCs form highly clustered network structures.

  • Because of this clustering, FRC networks resemble the famous small-world networks.

  • However, FRCs do not have the direct long-range connections of true small-world networks.

  • Permalink for 'IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression [TUMOR IMMUNOLOGY]' 22:00

    IL-21 Enhances the Development of Colitis-Associated Colon Cancer: Possible Involvement of Activation-Induced Cytidine Deaminase Expression [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Correction: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus [CORRECTIONS]' 22:00

    Correction: Pleiotropic Impacts of Macrophage and Microglial Deficiency on Development in Rats with Targeted Mutation of the Csf1r Locus [CORRECTIONS]

     » ‎ The Journal of Immunology
  • May 06, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'Report on the 2018 Cancer, Autoimmunity, and Immunology Conference [IMMUNOLOGY NOTES AND RESOURCES]' 22:00

    Report on the 2018 Cancer, Autoimmunity, and Immunology Conference [IMMUNOLOGY NOTES AND RESOURCES]

     » ‎ The Journal of Immunology
  • Permalink for 'The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity [BRIEF REVIEWS]' 22:00

    The Neuroimmune Axis in Skin Sensation, Inflammation, and Immunity [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1 [CUTTING EDGE]' 22:00

    Cutting Edge: Lymphomyeloid-Primed Progenitor Cell Fates Are Controlled by the Transcription Factor Tal1 [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Tal1 limits the number of ST-HSC priming lymphoid genes.

  • Tal1 limits the number of Rag2-GFP+ LMPPs.

  • Tal1 restrains the frequency of T lymphocyte–biased LMPPs.

  • Permalink for 'Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival [CUTTING EDGE]' 22:00

    Cutting Edge: Polymicrobial Sepsis Has the Capacity to Reinvigorate Tumor-Infiltrating CD8 T Cells and Prolong Host Survival [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • CLP-induced polymicrobial sepsis has the capacity to attenuate tumor growth.

  • Sepsis reinvigorates tumor-infiltrating CD8 T cells.

  • Checkpoint blockade after sepsis further improves survival of tumor-bearing hosts.

  • Permalink for 'Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Upstream Position of Proline Defines Peptide-HLA Class I Repertoire Formation and CD8+ T Cell Responses [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Proteomics analysis shows the upstream proline signature of HLA class I ligands.

  • Proline at upstream positions 1–3 attenuates CTL responses to a downstream epitope.

  • The finding contributes to prediction of naturally presented CTL epitopes.

  • Permalink for 'The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    The Activation State of CD4 T Cells Alters Cellular Peptidase Activities, HIV Antigen Processing, and MHC Class I Presentation in a Sequence-Dependent Manner [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Permalink for 'Trogocytosis-Mediated Intracellular Signaling in CD4+ T Cells Drives TH2-Associated Effector Cytokine Production and Differentiation [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Trogocytosis-Mediated Intracellular Signaling in CD4+ T Cells Drives TH2-Associated Effector Cytokine Production and Differentiation [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Trogocytosis-mediated signaling promotes IL-4 expression and TH2 differentiation.

  • TH2 cells perform trogocytosis more efficiently than TH1 or nonpolarized cells.

  • In vivo–generated, trogocytosis-positive cells are predominantly TH2.

  • Permalink for 'Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models [AUTOIMMUNITY]' 22:00

    Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • The covalent BTK inhibitor evobrutinib blocks B cell and myeloid cell activation.

  • Evobrutinib is efficacious in mouse models for RA, SLE, and cutaneous anaphylaxis.

  • Covalent binding allows modeling the relationship between BTK occupancy and efficacy.

  • Permalink for 'Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery [AUTOIMMUNITY]' 22:00

    Nur77 Links Chronic Antigen Stimulation to B Cell Tolerance by Restricting the Survival of Self-Reactive B Cells in the Periphery [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Nur77 expression correlates with the degree of autoreactivity of individual B cells.

  • Nur77 is dispensable for receptor editing, central deletion, and anergy.

  • Nur77 restrains the survival of mature self-reactive B cells.

  • Permalink for 'Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Mechanism for IL-15-Driven B Cell Chronic Lymphocytic Leukemia Cycling: Roles for AKT and STAT5 in Modulating Cyclin D2 and DNA Damage Response Proteins [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TLR9-primed human B-CLL clones respond to IL-15 with AKT and STAT5 activation.

  • PI3K/AKT and STAT5 pathways elevate cyclin D2 and repress ATM, TP53BP1, and MDC1.

  • Inhibitors of PI3K or STAT5 block in vitro B-CLL cycling induced by CpG DNA and IL-15.

  • Permalink for 'Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Immune Pharmacodynamic Responses of the Novel Cancer Immunotherapeutic Imprime PGG in Healthy Volunteers [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The pharmacological activity of Imprime is dependent on naturally occurring serum ABA.

  • A threshold of IgG ABA is necessary for Imprime-mediated innate immune responses.

  • It is likely that high-ABA subjects will be more prone to infusion-related reactions.

  • Permalink for 'The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination [IMMUNE REGULATION]' 22:00

    The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • The otubain YOD1 fine-tunes MAVS-RLR pathway–mediated antiviral immunity.

  • YOD1 interacts with MAVS on mitochondria.

  • YOD1 deubiquitinates MAVS and abrogates aggregation of MAVS.

  • Permalink for 'Regulation of Phospholipase D by Arf6 during Fc{gamma}R-Mediated Phagocytosis [IMMUNE REGULATION]' 22:00

    Regulation of Phospholipase D by Arf6 during Fc{gamma}R-Mediated Phagocytosis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Arf6 partially colocalized with PLD1 on vesicles and with PLD2 at the plasma membrane.

  • Active Arf6 is recruited to nascent phagosomes.

  • Arf6 regulates PLD activity and PA synthesis during phagocytosis.

  • Permalink for 'Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a{-}-C5aR1 Pathway [IMMUNE REGULATION]' 22:00

    Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a{-}-C5aR1 Pathway [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Myeloid-specific conditional deletion of BVR-A results in increased response to LPS.

  • Macrophages isolated from LysM-Cre:BVRfl/fl showed elevated levels of C5aR1.

  • Deletion of BVR-A resulted in enhanced macrophage chemotaxis toward C5a.

  • BVR-A–modulated chemotaxis and RANTES levels are dependent in part on C5aR1.

  • Permalink for 'Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4+ T Cell Memory [IMMUNE REGULATION]' 22:00

    Bach2 Negatively Regulates T Follicular Helper Cell Differentiation and Is Critical for CD4+ T Cell Memory [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Bach2 deletion in CD4+ T cells results in preferential Tfh cell differentiation.

  • The CXCR5 induction in the absence of Bach2 occurs before the upregulation of Ascl2.

  • Bach2 is critical for CD4+ T cell memory, including Tfh cell memory.

  • Permalink for 'Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT{beta}R Signaling [IMMUNE REGULATION]' 22:00

    Langerhans Cells Control Lymphatic Vessel Function during Inflammation via LIGHT-LT{beta}R Signaling [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • LCs express LIGHT, and chimeras lacking LIGHT in LCs have reduced skin DC migration.

  • Lymphatic endothelial cell–specific LTβR is required for skin DC migration.

  • LIGHT-LTβR signaling axis activates lymphatic endothelial CCL21/CCL19 expression.

  • Permalink for 'Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Malt1 is required for the development and function of Treg cells.

  • Malt1 protease activity in Treg cells could be a target for tumor therapy.

  • Permalink for 'Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Trauma Induces Emergency Hematopoiesis through IL-1/MyD88-Dependent Production of G-CSF [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Traumatic injury alone without infection can induce emergency hematopoiesis.

  • Trauma induces emergency hematopoiesis through IL-1 -dependent production of G-CSF.

  • Permalink for 'GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • ZIP requires GM-CSF and IRF4 signaling.

  • The ZIP macrophage phenotype is altered by a lack of GM-CSF or IRF4.

  • GM-CSF–IRF4 signaling upregulated MHCII expression in ZIP macrophages.

  • ZIP is independent of CCL17.

  • Permalink for 'TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut [MUCOSAL IMMUNOLOGY]' 22:00

    TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TLR2 plays a key role in gut serotonin production by both resident microbiota and a parasite.

  • TLR2 in nonhematopoietic cells is largely responsible for serotonin production in the gut.

  • We show TLR2 signaling–based novel mechanism of serotonin production in the gut.

  • Permalink for 'ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells [TRANSPLANTATION]' 22:00

    ST2/MyD88 Deficiency Protects Mice against Acute Graft-versus-Host Disease and Spares Regulatory T Cells [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • MyD88 deficiency in donor Tcons with Tregs protected against alloreactivity and aGVHD.

  • This protective effect uses ST2 but not the IL-1R or TLR4 pathways.

  • Permalink for 'FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway [TUMOR IMMUNOLOGY]' 22:00

    FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer [TUMOR IMMUNOLOGY]' 22:00

    Progesterone Receptor Attenuates STAT1-Mediated IFN Signaling in Breast Cancer [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • PR interacts with STAT1 in breast cancer cells.

  • PR attenuates IFN-induced STAT1 phosphorylation in breast cancer.

  • IFN signaling via STAT1 is more robust in breast cancer cells lacking PR.

  • Permalink for 'The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment [TUMOR IMMUNOLOGY]' 22:00

    The Angiotensin Receptor Blocker Losartan Suppresses Growth of Pulmonary Metastases via AT1R-Independent Inhibition of CCR2 Signaling and Monocyte Recruitment [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Losartan blocks CCL2–CCR2 monocyte recruitment to suppress lung metastasis growth.

  • Losartan functionally antagonizes CCL2–CCR2 ERK activation, independent of its AT1R target.

  • Permalink for 'Osmium-Labeled Microspheres for Bead-Based Assays in Mass Cytometry [NOVEL IMMUNOLOGICAL METHODS]' 22:00

    Osmium-Labeled Microspheres for Bead-Based Assays in Mass Cytometry [NOVEL IMMUNOLOGICAL METHODS]

     » ‎ The Journal of Immunology
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