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The Journal of Immunology (89 unread)

  • Permalink for 'TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2 [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2 [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Permalink for 'Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Essential Role of NADPH Oxidase-Dependent Production of Reactive Oxygen Species in Maintenance of Sustained B Cell Receptor Signaling and B Cell Proliferation [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • BCR ligation induces ROS production in two phases.

  • ROS production in the late phase is essential for B cell proliferation and survival.

  • ROS production in the late phase is mediated by NADPH oxidases, especially NOX3.

  • Permalink for 'Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • High DM overcomes poor DM/DQ2 interaction to inhibit DQ2 presentation of gliadin.

  • Relative low strength of gliadin peptide-DQ2 binding contributes when DM is high.

  • In contrast, abundant DM promotes DQ2 presentation of DM-resistant viral Ag.

  • Permalink for 'Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice [AUTOIMMUNITY]' 22:00

    Nanoparticles Bearing TSH Receptor Protein and a Tolerogenic Molecule Do Not Induce Immune Tolerance but Exacerbate Thyroid Autoimmunity in hTSHR/NOD.H2h4 Mice [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • TSHR A-subunit NOD.H2h4 mice spontaneously develop pathogenic TSHR Abs.

  • TSHR + ITE + A-subunit nanoparticles accelerated pathogenic TSHR Ab development.

  • TSHR A-subunit stimulation is required to generate pathogenic TSHR Abs.

  • Permalink for 'Expanded CD14hiCD16- Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Expanded CD14hiCD16- Immunosuppressive Monocytes Predict Disease Severity in Patients with Acute Pancreatitis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The proportion of CD14hiCD16 monocytes was increased in AP patients.

  • CD14hiCD16 monocyte proportions, together with their HLA-DR level, could predict AP severity.

  • Permalink for 'Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Cholecystokinin Downregulates Psoriatic Inflammation by Its Possible Self-Regulatory Effect on Epidermal Keratinocytes [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • We found that epidermal keratinocytes expressed CCK octapeptide.

  • CCK octapeptide expression was markedly decreased in acanthotic lesions of psoriasis.

  • CCK may exert a self-regulatory effect on psoriatic inflammation.

  • Permalink for 'Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders [IMMUNE REGULATION]' 22:00

    Stromal Interaction Molecule Deficiency in T Cells Promotes Spontaneous Follicular Helper T Cell Development and Causes Type 2 Immune Disorders [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance [IMMUNE REGULATION]' 22:00

    Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans [IMMUNOGENETICS]' 22:00

    Diversity of KIR, HLA Class I, and Their Interactions in Seven Populations of Sub-Saharan Africans [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • High levels of KIR and HLA diversity are present in all seven African populations.

  • Although 28 novel KIR alleles were detected, all HLA class I alleles are familiar.

  • KIRtelA and telB are balanced in East Africa, but KIRtelA dominates in West Africa.

  • Permalink for 'Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Identification and Characterization of Functional Human Monoclonal Antibodies to Plasmodium vivax Duffy-Binding Protein [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • P. vivax DPB:DARC interaction is essential for RBC invasion.

  • P. vivax–exposed individuals acquire Abs that block this interaction.

  • Human-derived monoclonal Abs recognize a globally conserved blocking epitope.

  • Permalink for 'Dragotcytosis: Elucidation of the Mechanism for Cryptococcus neoformans Macrophage-to-Macrophage Transfer [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Dragotcytosis: Elucidation of the Mechanism for Cryptococcus neoformans Macrophage-to-Macrophage Transfer [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • C. neoformans transfers between macrophages in coordinated exocytosis/phagocytosis.

  • Opsonin receptors are used for the transfer process.

  • C. neoformans must be viable for the transfer process to occur.

  • Permalink for 'Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Brucella abortus induces a STING-dependent UPR.

  • Bacterial c-di-GMP recognition by STING triggers B. abortus–induced UPR.

  • UPR blockade inhibits B. abortus replication in vitro and in vivo.

  • Permalink for 'Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Shifting Dynamics of Intestinal Macrophages during Simian Immunodeficiency Virus Infection in Adult Rhesus Macaques [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Lamina propria macrophages are short-lived and destroyed after SIV infection.

  • Intestinal submucosa macrophages are long-lived and may become SIV/HIV reservoirs.

  • Gut biopsies are insufficient for monitoring submucosal long-lived macrophages.

  • Permalink for 'Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • AB therapy in PD patients ablated P. gingivalis from oral and hematogenous reservoirs.

  • This reduced inflammatory blood mDCs and IL-1R expression on Tregs in PD patients.

  • A favorable clinical response was related to P. gingivalis ablation and a decrease in Treg->Th17.

  • Permalink for 'Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Distinctive Effects of GM-CSF and M-CSF on Proliferation and Polarization of Two Major Pulmonary Macrophage Populations [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome b [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Identification of Residues Critical for FPR2 Activation by the Cryptic Peptide Mitocryptide-2 Originating from the Mitochondrial DNA-Encoded Cytochrome b [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Critical structural elements are identified in MCT-2 that mediate FPR2 activation.

  • MCT-2 polymorphic variants activate human neutrophils with different potency.

  • Permalink for 'Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Skin wounding promotes Mo expansion in mouse bone marrow.

  • IL-1R1 signaling is not involved in skin wounding–induced Mo expansion.

  • Permalink for 'Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Leptin Promotes Monosodium Urate Crystal-Induced Inflammation in Human and Murine Models of Gout [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Acute gout patients express higher level of leptin and leptin receptor.

  • Leptin promotes MSU-induced inflammation in human and murine models of acute gout.

  • Leptin-exacerbating inflammation in acute gout is mediated by mTORC1 signaling.

  • Permalink for 'Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4-MyD88 Complex [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • DMF suppresses cytokine production in pDCs.

  • DMF blocks Myddosome formation by disrupting the MyD88–IRAK4 interaction.

  • DMF blocks the MyD88–IRAK4 interaction by targeting C13 in IRAK4.

  • Permalink for 'The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Immune Deficiency Pathway Regulates Metabolic Homeostasis in Drosophila [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • IMD activation in the fat body disrupts growth and energy stores.

  • Inhibition of IMD signaling in Drosophila disrupts metabolic homeostasis.

  • Insulin mutant flies have varied responses to bacterial infection.

  • Permalink for 'Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Epithelial Expression of an Interstitial Lung Disease-Associated Mutation in Surfactant Protein-C Modulates Recruitment and Activation of Key Myeloid Cell Populations in Mice [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • In a murine model of lung fibrosis, an ontogeny of inflammatory events was defined.

  • Mutant SftpcI73T expression caused early lung injury marked by a polycellular alveolitis.

  • Depletion of peripheral monocytes was protective from SftpcI73T injury.

  • Permalink for 'Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-{gamma} [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-{gamma} [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Ly-6Clo and Ly-6Chi monocytes/macrophages have unique roles in acute HILI.

  • Ly-6Clo monocytes/macrophages adopt proinflammatory phenotypes in CD11b-DTR+ mice.

  • Intranasal IFN- rescues CD11b-DTR+ mice from severe HILI.

  • Permalink for 'Integrin {beta}1 Promotes the Interaction of Murine IgG3 with Effector Cells [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Integrin {beta}1 Promotes the Interaction of Murine IgG3 with Effector Cells [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The mouse α4/β1 integrin is important in the binding of IgG3 Abs to macrophages.

  • Phagocytosis mediated by mIgG3 Abs depends on the α4/β1 integrin.

  • The α4/β1 integrin is a new receptor and/or part of a receptor complex for IgG3.

  • Permalink for 'Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality [TRANSPLANTATION]' 22:00

    Dendritic Cell Expression of Retinal Aldehyde Dehydrogenase-2 Controls Graft-versus-Host Disease Lethality [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells [TUMOR IMMUNOLOGY]' 22:00

    Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Correction: Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient B6.MRL-Faslpr mice/J Mice [CORRECTIONS]' 22:00

    Correction: Abrogation of Lupus Nephritis in Somatic Hypermutation-Deficient B6.MRL-Faslpr mice/J Mice [CORRECTIONS]

     » ‎ The Journal of Immunology
  • April 08, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases [BRIEF REVIEWS]' 22:00

    Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Nrf2 Regulates Neutrophil Recruitment and Accumulation in Skin during Contact Hypersensitivity [CUTTING EDGE]' 22:00

    Cutting Edge: Nrf2 Regulates Neutrophil Recruitment and Accumulation in Skin during Contact Hypersensitivity [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Permalink for 'Innate Control of Tissue-Reparative Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Innate Control of Tissue-Reparative Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Autoantibodies against Neurologic Antigens in Nonneurologic Autoimmunity [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Biased N-Glycosylation Site Distribution and Acquisition across the Antibody V Region during B Cell Maturation [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The Ab repertoire is diversified through the acquisition of N-glycosylation sites.

  • Frequencies of V region N-glycosylation sites are isotype and subclass dependent.

  • Elevated Fab glycosylation is an additional hallmark of TH2-like IgG4/IgE responses.

  • Permalink for 'Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6 [IMMUNE REGULATION]' 22:00

    Bach2 Controls T Follicular Helper Cells by Direct Repression of Bcl-6 [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity [IMMUNE REGULATION]' 22:00

    Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production [IMMUNE REGULATION]' 22:00

    Nonreceptor Tyrosine Kinase c-Abl- and Arg-Mediated IRF3 Phosphorylation Regulates Innate Immune Responses by Promoting Type I IFN Production [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • IRF3 is phosphorylated by Abl kinase family.

  • c-Abl and Arg regulate innate immunity by promoting type I IFN production.

  • AIM2 inflammasome activation during Ft LVS infection is prompted by Abl kinase.

  • Permalink for 'Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes [IMMUNE REGULATION]' 22:00

    Hepatitis B Virus-Induced Imbalance of Inflammatory and Antiviral Signaling by Differential Phosphorylation of STAT1 in Human Monocytes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Shp1-deficient iNKT cells are biased toward the iNKT2/17 subsets.

  • Shp1 deficiency does not alter TCR or Slam signaling.

  • Shp1 dampens iNKT cell proliferation in response to cytokines.

  • Permalink for 'NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    NKAP Must Associate with HDAC3 to Regulate Hematopoietic Stem Cell Maintenance and Survival [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • NKAP Y352 is required for association with HDAC3.

  • The interaction between NKAP and HDAC3 is critical for its function in HSCs.

  • The interaction between NKAP and HDAC3 is unimportant in some cell types.

  • Permalink for 'Sostdc1 Regulates NK Cell Maturation and Cytotoxicity [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Sostdc1 Regulates NK Cell Maturation and Cytotoxicity [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Sostdc1 influences tNK to mNK cell differentiation and the Ly49 receptor repertoire.

  • NK cells in Sostdc1–/– mice display impaired ability to kill β2m–/– target cells.

  • Sostdc1 expression in stromal and hematopoietic cells regulates NK cells.

  • Permalink for 'Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21 [IMMUNOTHERAPY AND VACCINES]' 22:00

    Enhancing Antigen Cross-Presentation in Human Monocyte-Derived Dendritic Cells by Recruiting the Intracellular Fc Receptor TRIM21 [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • We engineered the Fc of human IgG to increase its affinity for TRIM21 by 100-fold.

  • The engineered Fc enhances cross-presentation in monocyte-derived dendritic cells.

  • Our finding may be applied to vaccine design to boost CD8 T cell–based immunity.

  • Permalink for 'Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination [IMMUNOTHERAPY AND VACCINES]' 22:00

    Modified MHC Class II-Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Permalink for 'Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Permalink for 'Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • IFN-β promotes host resistance to M. tuberculosis via induction of NO production.

  • Capacity to inhibit IFN-β signaling correlates with mycobacterial virulence.

  • M. tuberculosis limits activation of receptor-associated tyrosine kinases TYK2 and JAK1.

  • Permalink for 'TLR4 Receptor Induces 2-AG-Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    TLR4 Receptor Induces 2-AG-Dependent Tolerance to Lipopolysaccharide and Trafficking of CB2 Receptor in Mast Cells [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Online Hemodiafiltration Inhibits Inflammation-Related Endothelial Dysfunction and Vascular Calcification of Uremic Patients Modulating miR-223 Expression in Plasma Extracellular Vesicles [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Online Hemodiafiltration Inhibits Inflammation-Related Endothelial Dysfunction and Vascular Calcification of Uremic Patients Modulating miR-223 Expression in Plasma Extracellular Vesicles [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Knockout of USP20 inhibits HSV-1– but not Sendai virus–triggered signaling.

  • USP20-deficient mice exhibit increased susceptibility to HSV-1 infection.

  • USP20 deconjugates K48-linked polyubiquitin chains from and thereby stabilizes MITA.

  • Permalink for 'FTRCA1, a Species-Specific Member of finTRIM Family, Negatively Regulates Fish IFN Response through Autophage-Lysosomal Degradation of TBK1 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    FTRCA1, a Species-Specific Member of finTRIM Family, Negatively Regulates Fish IFN Response through Autophage-Lysosomal Degradation of TBK1 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • FTRCA1 is a crucian carp–specific member of finTRIM.

  • FTRCA1 downregulates fish IFN response through lysosomal degradation of TBK1.

  • The E3 ligase activity is likely required for FTRCA1 function on TBK1 degradation.

  • Permalink for 'TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor-Mediated Signaling [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor-Mediated Signaling [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Vibrio cholerae OmpU Mediates CD36-Dependent Reactive Oxygen Species Generation Triggering an Additional Pathway of MAPK Activation in Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Vibrio cholerae OmpU Mediates CD36-Dependent Reactive Oxygen Species Generation Triggering an Additional Pathway of MAPK Activation in Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Loss of adipocyte and macrophage H2Ab1 leads to no change in metabolic phenotype.

  • Specific loss of macrophage H2Ab1 leads to improvements in glucose tolerance.

  • Adipocytes on HFD express LysM and are targeted by the LysMCre model.

  • Permalink for 'Notch Signaling Controls Transcription via the Recruitment of RUNX1 and MYB to Enhancers during T Cell Development [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Notch Signaling Controls Transcription via the Recruitment of RUNX1 and MYB to Enhancers during T Cell Development [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Notch favors RUNX1 and MYB recruitment to activate enhancer-dependent transcription.

  • These results decipher the mechanism for Tcrd and Tcrg silencing during β-selection.

  • Permalink for 'Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-{beta} to Induce IL-10-Producing Regulatory T Cells That Block Colitis [MUCOSAL IMMUNOLOGY]' 22:00

    Heligmosomoides polygyrus bakeri Infection Decreases Smad7 Expression in Intestinal CD4+ T Cells, Which Allows TGF-{beta} to Induce IL-10-Producing Regulatory T Cells That Block Colitis [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for '4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection [MUCOSAL IMMUNOLOGY]' 22:00

    4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Chromatin-Modifying Agent-Expanded Human Cord Blood Cells Display Reduced Allostimulatory Capacity [TRANSPLANTATION]' 22:00

    Chromatin-Modifying Agent-Expanded Human Cord Blood Cells Display Reduced Allostimulatory Capacity [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Bioluminescent Reporting of In Vivo IFN-{gamma} Immune Responses during Infection and Autoimmunity [NOVEL IMMUNOLOGICAL METHODS]' 22:00

    Bioluminescent Reporting of In Vivo IFN-{gamma} Immune Responses during Infection and Autoimmunity [NOVEL IMMUNOLOGICAL METHODS]

     » ‎ The Journal of Immunology
  • Permalink for 'Correction: The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics [CORRECTIONS]' 22:00

    Correction: The Goldilocks Zone of Type I IFNs: Lessons from Human Genetics [CORRECTIONS]

     » ‎ The Journal of Immunology
  • March 18, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 21:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'On the Road to Discovering the Elusive Executioner of Pyroptosis [PILLARS OF IMMUNOLOGY]' 21:00

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  • Permalink for 'Pillars Article: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006. 8: 1812-1825 [PILLARS OF IMMUNOLOGY]' 21:00

    Pillars Article: Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell Microbiol. 2006. 8: 1812-1825 [PILLARS OF IMMUNOLOGY]

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  • Permalink for 'An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses [BRIEF REVIEWS]' 21:00

    An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses [BRIEF REVIEWS]

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  • Permalink for 'Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes [CUTTING EDGE]' 21:00

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  • Permalink for 'Cutting Edge: G Protein Subunit {beta} 1 Negatively Regulates NLRP3 Inflammasome Activation [CUTTING EDGE]' 21:00

    Cutting Edge: G Protein Subunit {beta} 1 Negatively Regulates NLRP3 Inflammasome Activation [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Permalink for 'Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes [CLINICAL AND HUMAN IMMUNOLOGY]' 21:00

    Differential Influence of IL-9 and IL-17 on Actin Cytoskeleton Regulates the Migration Potential of Human Keratinocytes [CLINICAL AND HUMAN IMMUNOLOGY]

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  • Permalink for 'New Insights into Lymphocyte Differentiation and Aging from Telomere Length and Telomerase Activity Measurements [CLINICAL AND HUMAN IMMUNOLOGY]' 21:00

    New Insights into Lymphocyte Differentiation and Aging from Telomere Length and Telomerase Activity Measurements [CLINICAL AND HUMAN IMMUNOLOGY]

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  • Permalink for 'Glatiramer Acetate Stimulates Regulatory B Cell Functions [IMMUNE REGULATION]' 21:00

    Glatiramer Acetate Stimulates Regulatory B Cell Functions [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Permalink for 'Next Generation Sequencing of the Pig {alpha}{beta} TCR Repertoire Identifies the Porcine Invariant NKT Cell Receptor [IMMUNOGENETICS]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'Identification of Two Nonrearranging IgSF Genes in Chicken Reveals a Novel Family of Putative Remnants of an Antigen Receptor Precursor [IMMUNOGENETICS]' 21:00

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  • Permalink for 'A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity against Yersinia Infection in Adult and Infant Mice [IMMUNOTHERAPY AND VACCINES]' 21:00

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  • Permalink for 'Combined Blockade of TNF-{alpha} and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice [INFECTIOUS DISEASE AND HOST RESPONSE]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis [INNATE IMMUNITY AND INFLAMMATION]' 21:00

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  • Permalink for 'A20 Orchestrates Inflammatory Response in the Oral Mucosa through Restraining NF-{kappa}B Activity [INNATE IMMUNITY AND INFLAMMATION]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes [INNATE IMMUNITY AND INFLAMMATION]' 21:00

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  • Permalink for 'Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection [INNATE IMMUNITY AND INFLAMMATION]' 21:00

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  • Permalink for 'Self versus Nonself Discrimination by the Soluble Complement Regulators Factor H and FHL-1 [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 21:00

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  • Permalink for 'Oral Treatment with BT-11 Ameliorates Inflammatory Bowel Disease by Enhancing Regulatory T Cell Responses in the Gut [MUCOSAL IMMUNOLOGY]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'MAIT Cells Upregulate {alpha}4{beta}7 in Response to Acute Simian Immunodeficiency Virus/Simian HIV Infection but Are Resistant to Peripheral Depletion in Pigtail Macaques [MUCOSAL IMMUNOLOGY]' 21:00

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  • Permalink for 'Hypersensitive IFN Responses in Lupus Keratinocytes Reveal Key Mechanistic Determinants in Cutaneous Lupus [SYSTEMS IMMUNOLOGY]' 21:00

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  • Permalink for 'Programming Effects of Pubertal Lipopolysaccharide Treatment in Male and Female CD-1 Mice [SYSTEMS IMMUNOLOGY]' 21:00

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  • Permalink for 'Impact of KIR/HLA Incompatibilities on NK Cell Reconstitution and Clinical Outcome after T Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation with Posttransplant Cyclophosphamide [TRANSPLANTATION]' 21:00

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  • Permalink for 'ARTC2.2/P2RX7 Signaling during Cell Isolation Distorts Function and Quantification of Tissue-Resident CD8+ T Cell and Invariant NKT Subsets [NOVEL IMMUNOLOGICAL METHODS]' 21:00

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  • Permalink for 'FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers [NOVEL IMMUNOLOGICAL METHODS]' 21:00

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     » ‎ The Journal of Immunology
  • Permalink for 'Correction: Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis [CORRECTIONS]' 21:00

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     » ‎ The Journal of Immunology
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