Feeds

7066 items (7066 unread) in 32 feeds

Časopisi Časopisi
Podcast Podcast
Tisak Tisak
Web Web
 «  Expand/Collapse

The Journal of Immunology (82 unread)

  • Permalink for 'Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses [CUTTING EDGE]' 22:00

    Cutting Edge: CXCR3 Escapes X Chromosome Inactivation in T Cells during Infection: Potential Implications for Sex Differences in Immune Responses [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • A bicistronic dual-reporter mouse enables visualization of allelic CXCR3 expression.

  • CXCR3 escapes X chromosome inactivation (XCI) in T cells in vivo during infection.

  • XCI escape by CXCR3 potentially contributes to enhanced Th1 responses in females.

  • Permalink for 'Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1{beta} Maturation and ASC Speck Formation in Macrophages [CUTTING EDGE]' 22:00

    Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1{beta} Maturation and ASC Speck Formation in Macrophages [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Citrullination in macrophages is induced during pyroptosis.

  • The NLRP3 inflammasome is regulated by Ca2+-dependent PAD enzymes.

  • Permalink for 'Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection [CUTTING EDGE]' 22:00

    Cutting Edge: Tcf1 Instructs T Follicular Helper Cell Differentiation by Repressing Blimp1 in Response to Acute Viral Infection [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Tcf1-mediated repression of Blimp1 is functionally critical for TFH differentiation.

  • An intron-3 regulatory region in the Blimp1 gene is necessary for optimal TFH response.

  • Permalink for 'Cutting Edge: Bacillus Calmette-Guerin-Induced T Cells Shape Mycobacterium tuberculosis Infection before Reducing the Bacterial Burden [CUTTING EDGE]' 22:00

    Cutting Edge: Bacillus Calmette-Guerin-Induced T Cells Shape Mycobacterium tuberculosis Infection before Reducing the Bacterial Burden [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • BCG immunization alters the cell types targeted for early M. tuberculosis infection.

  • Vaccine-induced CD4 T cells are required for this transfer of infection.

  • T cell activation within the lung first occurs distal to sites of infection.

  • Permalink for 'Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell- and MyD88-Dependent Pathways in Mice [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell- and MyD88-Dependent Pathways in Mice [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Lone star tick proteins induce IgE production and hypersensitivity reactions in mice.

  • CD4+ T cell help is required for both sensitization and recall IgE production.

  • MyD88 deficiency in B cells disrupts IgE production.

  • Permalink for 'Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Allogenicity Boosts Extracellular Vesicle-Induced Antigen-Specific Immunity and Mediates Tumor Protection and Long-Term Memory In Vivo [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Injection of allogeneic Ag-loaded EVs significantly increases IgG in mice.

  • Two injections of syngeneic or allogeneic EVs result in long-term immunity.

  • Syngeneic and allogeneic EVs are equally potent in inhibiting tumor growth.

  • Permalink for 'Conditional Upregulation of IFN-{alpha} Alone Is Sufficient to Induce Systemic Lupus Erythematosus [AUTOIMMUNITY]' 22:00

    Conditional Upregulation of IFN-{alpha} Alone Is Sufficient to Induce Systemic Lupus Erythematosus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • We studied whether and to what extent IFN-α causes SLE.

  • We found that increase of IFN-α alone was sufficient to cause SLE.

  • The DNT cells as expanded by IFN-α directly caused organ manifestation of SLE.

  • Permalink for 'Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes [AUTOIMMUNITY]' 22:00

    Programmed Death-1 Restrains the Germinal Center in Type 1 Diabetes [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • PD-1 blockade or deficiency unleashes follicular insulin-specific CD4+ T and B cells.

  • PD-1 limits T follicular helper cell survival in the germinal center.

  • PD-1 blockade increases insulin autoantibody production in diabetes-prone mice.

  • Permalink for 'Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Cholesterol crystals induce coagulation through monocyte TF.

  • Monocyte TF induction is blocked by complement inhibitors to C3, C5, or C5aR1.

  • Monocyte TF induction is dependent on complement C5aR1.

  • Permalink for 'Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2 [IMMUNE REGULATION]' 22:00

    Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2 [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • COX-1 deficiency impaired TFH cell development during influenza infection and KLH immunization.

  • COX-1–derived metabolite PGE2 and its receptors EP2/EP4 mediate the effect of COX-1 on TFH cells.

  • Permalink for 'Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions [IMMUNE REGULATION]' 22:00

    Identification of the E3 Ligase TRIM29 as a Critical Checkpoint Regulator of NK Cell Functions [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • TRIM29 is induced in NK cells and inhibits NK functions.

  • TRIM29 deletion in NK cells enhances IFN- production.

  • TRIM29 ubiquitinates and degrades TAB2 in activated NK cells.

  • Permalink for 'TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    TCR Affinity for In Vivo Peptide-Induced Thymic Positive Selection Fine-Tunes TCR Responsiveness of Peripheral CD8+ T Cells [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • In vivo administration of a peptide can promote T cell selection in the thymus.

  • Affinity for TCR/pMHC during positive selection fine-tunes peripheral T cells.

  • Permalink for 'IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis [IMMUNOGENETICS]' 22:00

    IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • MS-associated SNP rs17066096 influences IL-22BP levels.

  • IL-22BP promotes neuroinflammation by blocking IL-22 signaling.

  • IL-22 reduces T cell IFN- production.

  • Permalink for 'Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight [IMMUNOTHERAPY AND VACCINES]' 22:00

    Kynurenine 3-Monooxygenase Inhibition during Acute Simian Immunodeficiency Virus Infection Lowers PD-1 Expression and Improves Post-Combination Antiretroviral Therapy CD4+ T Cell Counts and Body Weight [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • KMO inhibition improved clinical outcomes of CD4+ T cell counts and body weight.

  • KMO inhibition increased naive T cell frequency and lowered PD-1 expression.

  • Permalink for 'IL-1{beta} Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    IL-1{beta} Induces the Rapid Secretion of the Antimicrobial Protein IL-26 from Th17 Cells [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • TLR ligands induce IL-26 secretion from PBMCs in an IL-1β–dependent manner.

  • IL-1β induces rapid IL-26 release by IL-1RI+ Th17 cells without TCR activation.

  • IL-1β–stimulated T cells mediate an antimicrobial activity via IL-26.

  • Permalink for 'IL-36{gamma} Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    IL-36{gamma} Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • IL-36 conferred MDMs M. tuberculosis resistance through activation of autophagy.

  • IL-36 induced autophagy relying on WNT5A/COX-2/AKT/mTOR axis.

  • IL-36 may be a potential candidate for immune therapy of tuberculosis.

  • Permalink for 'The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    The Impact of TCR Signal Strength on Resident Memory T Cell Formation during Influenza Virus Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Low affinity–stimulated CD8+ T cells have an advantage in forming TRM.

  • High and low affinity–stimulated TRM have distinct transcriptomes.

  • TRM longevity is not impacted by strength of TCR stimulation.

  • Permalink for 'The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    The Functional Requirement for CD69 in Establishment of Resident Memory CD8+ T Cells Varies with Tissue Location [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • CD69 is not required for the establishment of CD8+ TRM in every nonlymphoid tissue.

  • In the kidney, CD69 is required for CD8+ TRM regardless of immunization approach.

  • CD69 deficiency prevents generation of KLF2low TRM in the kidney.

  • Permalink for 'The Metabolic Cytokine Adiponectin Inhibits Inflammatory Lung Pathology in Invasive Aspergillosis [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    The Metabolic Cytokine Adiponectin Inhibits Inflammatory Lung Pathology in Invasive Aspergillosis [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Adiponectin KO mice show increased pathology in a mouse model of IA.

  • KO mice show increased inflammatory and decreased anti-inflammatory phenotypes.

  • Increased lung inflammation in KO mice is independent of invasive fungal growth.

  • Permalink for 'NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Deficiency of NK cells leads to enhanced susceptibility to T. congolense infection.

  • NK cells mediate protection during T. congolense infection via perforin.

  • Permalink for 'A Subset of Mycobacteria-Specific CD4+ IFN-{gamma}+ T Cell Expressing Naive Phenotype Confers Protection against Tuberculosis Infection in the Lung [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    A Subset of Mycobacteria-Specific CD4+ IFN-{gamma}+ T Cell Expressing Naive Phenotype Confers Protection against Tuberculosis Infection in the Lung [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • We describe a naive-like M. tuberculosis–specific CD4+ IFN-+ memory T cell (TNLM).

  • TNLM provide protection equal to known memory subsets against M. tuberculosis lung infection.

  • Permalink for 'KLF12 Regulates Mouse NK Cell Proliferation [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    KLF12 Regulates Mouse NK Cell Proliferation [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • KLF12 deficiency does not affect NK cell development and effector functions.

  • KLF12-deficient NK cells have increased expression of Btg3 and the IL-21 receptor.

  • IL-21 induced Btg3 and inhibited KLF12-deficient NK cell proliferation.

  • Permalink for 'Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPK{alpha} Pathway in Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Tim-4 Inhibits NLRP3 Inflammasome via the LKB1/AMPK{alpha} Pathway in Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • NAFLD microenvironments increase Tim-4 expression in macrophages.

  • Tim-4 in macrophages suppresses NLRP3 inflammasome depending on PS binding motif.

  • Tim-4 promotes phosphorylation of AMPKα by interacting with LKB1.

  • Permalink for 'NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    NAC1 Potentiates Cellular Antiviral Signaling by Bridging MAVS and TBK1 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • NAC1 enhances the virus-induced IFN signaling and activation of TBK1 and IRF3.

  • NAC1 inhibits the replication of RNA viruses.

  • NAC1 promotes the recruitment of TBK1 to MAVS upon viral infection.

  • Permalink for 'Noncanonical Role of FBXO6 in Regulating Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Noncanonical Role of FBXO6 in Regulating Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • FBXO6 can negatively regulate the activation of IFN-I signaling.

  • FBXO6 interacts with and mediates IRF3 degradation independent of SCF complex.

  • Permalink for 'Azithromycin Polarizes Macrophages to an M2 Phenotype via Inhibition of the STAT1 and NF-{kappa}B Signaling Pathways [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Azithromycin Polarizes Macrophages to an M2 Phenotype via Inhibition of the STAT1 and NF-{kappa}B Signaling Pathways [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • AZM’s immunomodulatory mechanism involves both NF-B and STAT1 pathways.

  • AZM’s impact on STAT1 phosphorylation works in part through IKKβ.

  • Permalink for 'Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Vacuolar (H+)-ATPase Critically Regulates Specialized Proresolving Mediator Pathways in Human M2-like Monocyte-Derived Macrophages and Has a Crucial Role in Resolution of Inflammation [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • V-ATPase is required for ERK-mediated 15-LOX-1 expression during M2 polarization.

  • Inhibition of V-ATPase prevents 15-LOX-1–mediated SPM biosynthesis in M2 macrophages.

  • Targeting V-ATPase delays resolution in murine peritonitis with decreased SPM levels.

  • Permalink for 'Early T-BET Expression Ensures an Appropriate CD8+ Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Early T-BET Expression Ensures an Appropriate CD8+ Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Early T-BET expression is important for early acquisition of CD8+ T cell lineage–specific function.

  • T-BET expression shuts down inappropriate T cell lineage functions in activated CD8+ T cells.

  • Early T-BET expression is required for activation of specific IFN- transcriptional enhancers.

  • Permalink for 'Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Carboxyl-Terminal Src Kinase Binds CD28 upon Activation and Mutes Downstream Signaling [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The interactomes of CD2 and CD28 were identified.

  • CSK is a specific and direct interactor of activated CD28.

  • CSK regulates signaling downstream of CD28.

  • Permalink for 'Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection [SYSTEMS IMMUNOLOGY]' 22:00

    Semiquantitative Proteomics Enables Mapping of Murine Neutrophil Dynamics following Lethal Influenza Virus Infection [SYSTEMS IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Neutrophil proteomes are mapped during homeostasis or following lethal PR8 infection.

  • ISGs are first elevated in BM and then BAL neutrophils following lethal PR8 infection.

  • BAL neutrophil proteomes exhibit a modest capacity for pathogen tuning.

  • Permalink for 'LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells [TUMOR IMMUNOLOGY]' 22:00

    LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • LILRB1 inhibits BiTE molecule–induced cytolytic activity of human CD8+ T cells.

  • LILRB1 and PD1 express on distinct human CD8+ T cell subsets in tumors.

  • LILRB1 and PD1 blockades have synergistic effects to enhance CD8+ T cell activity.

  • July 22, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'T Cell-Activating Bispecific Antibodies in Cancer Therapy [TRANSLATING IMMUNOLOGY]' 22:00

    T Cell-Activating Bispecific Antibodies in Cancer Therapy [TRANSLATING IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Intestinal Macrophages in Resolving Inflammation [BRIEF REVIEWS]' 22:00

    Intestinal Macrophages in Resolving Inflammation [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts [CUTTING EDGE]' 22:00

    Cutting Edge: Synapse Propensity of Human Memory CD8 T Cells Confers Competitive Advantage over Naive Counterparts [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Microcontact printing can be used to mimic spatially limiting Ag presentation.

  • High synapse propensity of human memory CD8 T cells prevents naive cell recruitment.

  • Permalink for 'Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human V{gamma}2V{delta}2 T Cells [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Critical Roles for Coiled-Coil Dimers of Butyrophilin 3A1 in the Sensing of Prenyl Pyrophosphates by Human V{gamma}2V{delta}2 T Cells [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • Part of the juxtamembrane of BTN3A1 proteins forms a coiled-coil dimer.

  • The coiled-coil dimer is critical for BTN3A1 stimulation of V2V2 T cells.

  • B30.2 domains of BTN3A1 proteins also dimerize through a short coiled-coil region.

  • Permalink for 'Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Coexpression of YY1 Is Required to Elaborate the Effector Functions Controlled by PLZF in NKT Cells [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • YY1-deficient NKT cells display cell-intrinsic developmental and functional defects.

  • YY1-deficient NKT cells maintain wild-type levels of PLZF expression.

  • YY1 and PLZF proteins associate with one another.

  • Permalink for 'CD27 Promotes CD4+ Effector T Cell Survival in Response to Tissue Self-Antigen [AUTOIMMUNITY]' 22:00

    CD27 Promotes CD4+ Effector T Cell Survival in Response to Tissue Self-Antigen [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • The CD27 pathway on CD4+ T cells plays a role in driving skin autoimmunity.

  • CD27 signaling promotes survival by suppressing cell-extrinsic apoptosis.

  • Permalink for 'Thymus-Derived Regulatory T Cells Exhibit Foxp3 Epigenetic Modification and Phenotype Attenuation after Mating in Mice [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Thymus-Derived Regulatory T Cells Exhibit Foxp3 Epigenetic Modification and Phenotype Attenuation after Mating in Mice [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Seminal fluid primes Treg cells to elicit tolerance of male alloantigens.

  • Neuropilin-1+ Tregs of likely thymic origin are prevalent amongst responding T cells.

  • Neuropilin-1+ Tregs exhibit Foxp3 TSDR demethylation after seminal fluid contact.

  • Permalink for 'The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function [IMMUNE REGULATION]' 22:00

    The Transcriptional Regulator Id2 Is Critical for Adipose-Resident Regulatory T Cell Differentiation, Survival, and Function [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • The transcriptional regulator Id2 is highly expressed in aTregs.

  • Id2 is critical for the survival of aTregs.

  • Id2 is essential for the function of aTregs in preventing systemic inflammation.

  • Permalink for 'The Alzheimers Disease-Associated Protein BACE1 Modulates T Cell Activation and Th17 Function [IMMUNE REGULATION]' 22:00

    The Alzheimers Disease-Associated Protein BACE1 Modulates T Cell Activation and Th17 Function [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • BACE1 is expressed in CD4+ T cells and regulates signaling events during activation.

  • BACE1-deficient T cells show reduced IL-17A expression in vitro.

  • BACE1–/– Th17 cells have impaired pathogenicity in EAE.

  • Permalink for 'CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation [IMMUNE REGULATION]' 22:00

    CD137 (4-1BB) Engagement Fine-Tunes Synergistic IL-15- and IL-21-Driven NK Cell Proliferation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Three signals are required to trigger NK cell proliferation.

  • 4-1BBL fine-tunes NK cell proliferation but not NK cell cytolytic activity.

  • Permalink for 'Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • REs critical for Foxn1 expression are in the first intron of Foxn1.

  • These elements are necessary for Foxn1 expression in TECs.

  • These elements are not required for Foxn1 expression in the skin.

  • Permalink for 'Treatment of Experimental Autoimmune Encephalomyelitis by Sustained Delivery of Low-Dose IFN-{alpha} [IMMUNOTHERAPY AND VACCINES]' 22:00

    Treatment of Experimental Autoimmune Encephalomyelitis by Sustained Delivery of Low-Dose IFN-{alpha} [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Recombinant adeno-associated virus expresses low and sustained levels of IFN-α.

  • AAV–IFN-α exerts a potent therapeutic effect and low toxicity in an EAE animal model.

  • Permalink for 'NK Response Correlates with HIV Decrease in Pegylated IFN-{alpha}2a-Treated Antiretroviral Therapy-Suppressed Subjects [IMMUNOTHERAPY AND VACCINES]' 22:00

    NK Response Correlates with HIV Decrease in Pegylated IFN-{alpha}2a-Treated Antiretroviral Therapy-Suppressed Subjects [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • KIRs and NK cytotoxicity correlate with HIV control upon IFN-α immunotherapy.

  • NK activity–associated genes correlate with HIV DNA decline upon IFN-α immunotherapy.

  • A gene signature identifies subjects with no ISG modulation upon IFN-α immunotherapy.

  • Permalink for 'TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    TRAILshort Protects against CD4 T Cell Death during Acute HIV Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • TRAIL binding to TRAIL receptor R1 and R2 contributes to CD4 death during HIV infection.

  • Blocking TRAILshort, a TRAIL antagonist, increases death of HIV-infected and uninfected cells.

  • Homeostatic production of TRAILshort may protect cells from HIV-induced cell death.

  • Permalink for 'Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Sepsis-Induced State of Immunoparalysis Is Defined by Diminished CD8 T Cell-Mediated Antitumor Immunity [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Immunoparalysis phase of sepsis is characterized by increased tumor progression.

  • Effector PD-1hi CD8 TILs are reduced in frequency/function in sepsis survivors.

  • Checkpoint blockade therapy has a diminished window of efficacy in sepsis survivors.

  • Permalink for 'The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1{beta} Release [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1{beta} Release [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • MSU crystals and alum rapidly activate GSDMD.

  • GSDMD is dispensable for MSU crystal– and alum-induced IL-1β release and cell death.

  • Cathepsins, caspases, and MLKL are not required for MSU crystal–induced cell killing.

  • Permalink for 'SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses [SYSTEMS IMMUNOLOGY]' 22:00

    SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses [SYSTEMS IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Automated machine learning approach to identify vaccine-induced immune signatures.

  • Analysis of multidimensional clinical data collected across multiple cohorts.

  • Increasing predictive performance of models by using heterogenous clinical data.

  • Permalink for 'Dynamic Mitochondrial Migratory Features Associated with Calcium Responses during T Cell Antigen Recognition [NOVEL IMMUNOLOGICAL METHODS]' 22:00

    Dynamic Mitochondrial Migratory Features Associated with Calcium Responses during T Cell Antigen Recognition [NOVEL IMMUNOLOGICAL METHODS]

     » ‎ The Journal of Immunology
  • Microfluidics provides precision for manipulating cell–cell interactions.

  • Complex mitochondrial movement occurs during initial T cell:APC synapse formation.

  • Mitochondrial positioning is a strong predictor of calcium response.

  • Permalink for 'Correction: Exosomes Derived from Burkitts Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells [CORRECTIONS]' 22:00

    Correction: Exosomes Derived from Burkitts Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells [CORRECTIONS]

     » ‎ The Journal of Immunology
  • July 08, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for '{gamma}{delta} T Cell Update: Adaptate Orchestrators of Immune Surveillance [BRIEF REVIEWS]' 22:00

    {gamma}{delta} T Cell Update: Adaptate Orchestrators of Immune Surveillance [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection [CUTTING EDGE]' 22:00

    Cutting Edge: Transcription Factor BCL6 Is Required for the Generation, but Not Maintenance, of Memory CD8+ T Cells in Acute Viral Infection [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • BCL6 is dispensable for the maintenance of memory CD8+ T cells.

  • BCL6 is required for the generation of CD8+ memory precursors.

  • BCL6 promotes TCF-1 expression in CD8+ memory precursors.

  • Permalink for 'Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common {beta}-Chain Cytokines IL-5 and GM-CSF [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    Human Eosinophils Express a Distinct Gene Expression Program in Response to IL-3 Compared with Common {beta}-Chain Cytokines IL-5 and GM-CSF [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • β-Chain receptor cytokines produce a proinflammatory and survival phenotype.

  • IL-3 stimulation yields a distinct eosinophil gene expression program.

  • IL-3–upregulated hub genes may have implications in future asthma therapeutics.

  • Permalink for 'Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells [AUTOIMMUNITY]' 22:00

    Metformin Inhibits the Type 1 IFN Response in Human CD4+ T Cells [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Metformin affects gene expression in HC and SLE patient CD4 T cells.

  • Metformin reduces activation of T1 IFN–stimulated genes in CD4 T cells.

  • Inhibition of ETC activity reduces T1 IFN response.

  • Permalink for 'A Novel Animal Model of Emphysema Induced by Anti-Elastin Autoimmunity [AUTOIMMUNITY]' 22:00

    A Novel Animal Model of Emphysema Induced by Anti-Elastin Autoimmunity [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • A novel model of autoimmunity against elastin resulted in emphysema.

  • Elastin-specific TCR sequences identified autoreactive T cell clones in the lung.

  • Permalink for 'Angiogenic and Arthritogenic Properties of the Soluble Form of CD13 [AUTOIMMUNITY]' 22:00

    Angiogenic and Arthritogenic Properties of the Soluble Form of CD13 [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Soluble CD13 (sCD13) is a potent angiogenic factor in vitro and ­­­in vivo.

  • sCD13 induces acute inflammatory arthritis in mice and induces MN migration via GPCR.

  • sCD13 increases cytokine secretion and phosphorylation of signaling molecules.

  • Permalink for 'Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells [IMMUNE REGULATION]' 22:00

    Helios Deficiency Predisposes the Differentiation of CD4+Foxp3- T Cells into Peripherally Derived Regulatory T Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Mice with a deficiency of Helios in all T cells do not develop autoimmunity.

  • Although Ag-specific Helios–/– CD4+ T cells prime normally, they become tolerant.

  • pTreg cells are generated in the absence of Helios and mediate the tolerant state.

  • Permalink for 'Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells [IMMUNE REGULATION]' 22:00

    Follicular B2 Cell Activation and Class Switch Recombination Depend on Autocrine C3ar1/C5ar1 Signaling in B2 Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • C3ar1/C5ar1 signaling supports B2 cell activation, IL-6, AID/Bcl-6, and CSR.

  • B2 cells locally produce factor I as well as C3 enabling autocrine CD21 signaling.

  • Ab production and CSR are augmented in the absence of DAF (CD55).

  • Permalink for 'Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation [IMMUNE REGULATION]' 22:00

    Signaling Cascade through DC-ASGPR Induces Transcriptionally Active CREB for IL-10 Induction and Immune Regulation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • DC-ASGPR induces IL-10 expression mainly through the activation of ERK/p90RSK/CREB.

  • DC-ASGPR–induced Akt/GSK-3/β-catenin activation contributes to IL-10 induction.

  • DC-ASGPR can play an important role in controlling host immune responses.

  • Permalink for 'Skint8, a Novel B7 Family-Related Molecule, Negatively Regulates T Cell Responses [IMMUNE REGULATION]' 22:00

    Skint8, a Novel B7 Family-Related Molecule, Negatively Regulates T Cell Responses [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Skint8 shares sequence and structural similarity to existing B7 family members.

  • Skint8-Ig fusion protein inhibits T cell functions in vitro.

  • Skint8-Ig alleviates experimental autoimmune encephalomyelitis in mice.

  • Permalink for 'Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Murine T Cell Maturation Entails Protection from MBL2, but Complement Proteins Do Not Drive Clearance of Cells That Fail Maturation in the Absence of NKAP [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • In vivo, T cell maturation entails increasing resistance to complement proteins.

  • In vitro, MBL2 is required for complement deposition on immature thymocytes.

  • NKAP-deficient T cells that fail maturation die by ferroptosis, not by complement.

  • Permalink for 'Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Optimal Development of Mature B Cells Requires Recognition of Endogenous Antigens [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Tonic BCR signaling is not sufficient for optimal development of any B cell lineage.

  • Ag recognition is required for development not only of B1a, but also of B2 cells.

  • The minimal threshold for Ag recognition is higher for MZ than for Fo B2 cells.

  • Permalink for 'Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1{alpha}-RIG-I Antiviral Signaling [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1{alpha}-RIG-I Antiviral Signaling [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • FMDV infection activates two UPR branches: PERK-eIF2α and ATF6 signaling.

  • FMDV infection suppresses the IRE1α-XBP1 pathway of the UPR.

  • Sec62 suppresses FMDV replication by promotion of IRE1α–RIG-I antiviral signaling.

  • Permalink for 'Protease-Activated Receptor 2 Agonist as Adjuvant: Augmenting Development of Protective Memory CD8 T Cell Responses Induced by Influenza Virosomes [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Protease-Activated Receptor 2 Agonist as Adjuvant: Augmenting Development of Protective Memory CD8 T Cell Responses Induced by Influenza Virosomes [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • PAR-2–activating peptide can act as an adjuvant when delivered to lung.

  • PAR-2–activating peptide plus flu virosomes protect from influenza infection.

  • PAR-2–activating peptide increases the frequency of memory CD8+ T cells in lung.

  • Permalink for 'Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Lactic Acid Inhibits Lipopolysaccharide-Induced Mast Cell Function by Limiting Glycolysis and ATP Availability [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Lactic acid suppresses LPS-mediated mast cell function.

  • Suppression required the MCT-1 transporter and reduced NF-B function.

  • Lactic acid suppresses LPS-induced glycolysis; these effects are linked to suppression.

  • Permalink for 'Viral Resistance and IFN Signaling in STAT2 Knockout Fish Cells [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Viral Resistance and IFN Signaling in STAT2 Knockout Fish Cells [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • A stat2–/– Oncorhynchus tshawytscha cell line was isolated.

  • STAT2 is required for type I but not type II signaling in salmonid cells.

  • Permalink for 'Eosinophils Do Not Drive Acute Muscle Pathology in the mdx Mouse Model of Duchenne Muscular Dystrophy [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Eosinophils Do Not Drive Acute Muscle Pathology in the mdx Mouse Model of Duchenne Muscular Dystrophy [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Eosinophils are prominent in quadriceps lesions of dystrophin-deficient mdx mice.

  • Muscle damage was evaluated quantitatively in mdx, mdx.PHIL, and mdx.IL5tg mice.

  • In these models, eosinophil infiltration is not driving acute muscle pathology.

  • Permalink for 'Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the {alpha}7 Nicotinic Acetylcholine Receptor [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Nicotine Attenuates Osteoarthritis Pain and Matrix Metalloproteinase-9 Expression via the {alpha}7 Nicotinic Acetylcholine Receptor [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Nicotine can attenuate joint inflammation and pain in experimental OA via α7-nAChRs.

  • Nicotine inhibits MMP-9 production by macrophages through the PI3K/Akt/NF-B pathway.

  • Permalink for 'Extracellular Polyphosphate Promotes Macrophage and Fibrocyte Differentiation, Inhibits Leukocyte Proliferation, and Acts as a Chemotactic Agent for Neutrophils [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Extracellular Polyphosphate Promotes Macrophage and Fibrocyte Differentiation, Inhibits Leukocyte Proliferation, and Acts as a Chemotactic Agent for Neutrophils [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Polyphosphate released from platelets induces fibrocyte differentiation.

  • Polyphosphate can act as a chemoattractant for neutrophils.

  • Permalink for 'Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Lipopolysaccharide-Stimulated Human Fetal Membranes Induce Neutrophil Activation and Release of Vital Neutrophil Extracellular Traps [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Resting FMs induce low levels of neutrophil cytokine secretion and vital NET release.

  • LPS-stimulated FMs augment neutrophil activation and vital NET release via TNF-α.

  • NET release induced by LPS-stimulated FMs was ROS and p38 MAP kinase dependent.

  • Permalink for 'Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Wnt4 is a noncanonical Wnt protein that is expressed in stroma and cDC.

  • Wnt4 is both necessary and sufficient for maintenance of cDC1.

  • Lack of DC-derived Wnt4 accelerates type 2 immunity.

  • Permalink for 'Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Cytokine Diversity in Human Peripheral Blood Eosinophils: Profound Variability of IL-16 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Eosinophils are heterogeneous with natural variations in cytokine content.

  • Eosinophil IL-16 content varies dramatically among normal donors (CV = 103%).

  • Eosinophil IL-16 content may correlate directly with donor BMI (R2 = 0.60).

  • Permalink for 'CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection [MUCOSAL IMMUNOLOGY]' 22:00

    CRTAM Shapes the Gut Microbiota and Enhances the Severity of Infection [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The presence of CRTAM impacts the gut microbiota during homeostasis and infection.

  • CRTAM-mediated responses enhance Salmonella gut infection.

  • Transplanted gut microbiota modulates CRTAM expression in ex–germ-free mice.

  • Permalink for 'NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death [MUCOSAL IMMUNOLOGY]' 22:00

    NLRP6 Deficiency in CD4 T Cells Decreases T Cell Survival Associated with Increased Cell Death [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The differentiation of naive T cells into Th1 cells induces the expression of Nlrp6.

  • The expression of Nlrp6 by Th1 cells depends on the microbiota.

  • Nlrp6 deficiency in T cells activates caspase-1 associated with cell death.

  • Permalink for 'Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease [TRANSPLANTATION]' 22:00

    Early Notch Signals Induce a Pathogenic Molecular Signature during Priming of Alloantigen-Specific Conventional CD4+ T Cells in Graft-versus-Host Disease [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • Notch signals in conventional CD4+ T cells are essential for GVHD pathogenesis.

  • Notch induces a unique molecular signature during priming of alloreactive T cells.

  • Permalink for 'Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult {gamma}{delta} T Cell Development [NOVEL IMMUNOLOGICAL METHODS]' 22:00

    Proximal Lck Promoter-Driven Cre Function Is Limited in Neonatal and Ineffective in Adult {gamma}{delta} T Cell Development [NOVEL IMMUNOLOGICAL METHODS]

     » ‎ The Journal of Immunology
  • pLckCre inefficiently deletes floxed genes in T cells generated in the adult.

  • pLckCre expression mainly effects T cells developing early in ontogeny.

  • Endogenous Lck expression is diminished in developing compared with αβ T cells.

  • Permalink for 'Correction: Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation [CORRECTIONS]' 22:00

    Correction: Palmitate Conditions Macrophages for Enhanced Responses toward Inflammatory Stimuli via JNK Activation [CORRECTIONS]

     » ‎ The Journal of Immunology
  • ← The Journal of General Physiology Science Magazine Podcast →