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The Journal of Immunology (100 unread)

 
  • Permalink for 'The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Pglyrp1 enhances allergic asthma in mice through its effect on the intestinal microbiome.

  • This effect is strong in asthma-prone mice and weak in asthma-resistant outbred mice.

  • This effect requires germ-free mice before colonization with the Pglyrp1 microbiome.

  • Permalink for 'Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • IgG fucosylation status and target cell Ag density determine NK cell ADCC.

  • Aspecific serum IgG bound to FcRIIIa and target cell glycocalyx limit NK cell ADCC.

  • NK cell FcRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.

  • Permalink for 'Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]' 22:00

    Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Anti-C3d mAb 3d-8b blocks in vivo CR2-dependent Ab production to foreign Ags.

  • Anti-C3d mAb 3d-8b is capable of blocking in vivo iC3b/C3d from CR1/CR2.

  • Disruption of the B cell–CR2 costimulatory signal reduces autoantibody production.

  • Permalink for 'TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TNF-producing CD4+ T cells in patients with AIH are significantly expanded.

  • Most TNF-producing T cells also produce IFN- and have an inflammatory phenotype.

  • Autoantigen-specific stimulation results in expansion of these inflammatory T cells.

  • Permalink for 'CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Chemokine ligand CCL2 is cleared from the blood in a CCR2-dependent manner.

  • CCR2-dependent clearance of CCL2 is G protein (Gαi, Gαs, or Gαq/11) independent.

  • Equilibrium between secretion of CCL2 and its uptake by CCL2 determines blood levels.

  • Permalink for 'Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CRISPR gene disruption in CD4+ T cells is enhanced by donor DNA template delivery.

  • Disruption of key signaling proteins in human CD4+ T cells mimics murine data.

  • Hyperactive signaling in human T cells can drive compensatory regulatory responses.

  • Permalink for 'CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CXCR3 identifies human naive CD8+ T cells with biased effector potential.

  • Human naive CD8+ T cell subsets are functionally and transcriptionally distinct.

  • Effector potential correlates with the physicochemical attributes of expressed TCRs.

  • Permalink for 'Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Circulating intermediate monocytes are enriched in AH patients.

  • AH intermediate monocytes are functionally activated.

  • AH intermediate monocytes induce CD4+ T cell IL-17 and are enriched in the liver.

  • Permalink for 'Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]' 22:00

    Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • A high-fiber diet attenuates arthritis in a microbiota-dependent manner.

  • Butyrate attenuates arthritis in an iNKT cell–dependent manner.

  • Butyrate inhibits cytokine production of iNKT cells in an HDAC-dependent manner.

  • Permalink for 'The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]' 22:00

    The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RORα deficiency leads to a reduction in ILC2 and ILC3 subsets during infection.

  • Residual Rorasg/sg ILC3s have lower expression of Rorc and lineage-specific receptors.

  • RORα conserves ILC3 function by modulating integration of environmental cues.

  • Permalink for 'CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]' 22:00

    CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • FcR activation in human monocytes regulates the localization and expression of CD31.

  • FcR-mediated CD31 downregulation is mediated mainly through FcRIIa and PI3K.

  • CD31 negatively regulates FcR-mediated phagocytosis but not cytokine production.

  • Permalink for 'OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]' 22:00

    OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • OX40L-JAG1 induced Treg proliferation mediated via noncanonical NF-B signaling.

  • OX40L-JAG1 expanded epigenetically stable and suppressive Tregs to ameliorate EAT.

  • OX40L-JAG1 induced TCR-independent selective proliferation of human thymic Tregs.

  • Permalink for 'Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]' 22:00

    Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Western diet feeding increases Nrp1 on Foxp3 CD4 T cells in ApoE–/– mice.

  • Nrp1+Foxp3 CD4 T cells are highly proliferative and atherogenic.

  • Nrp1+Foxp3 CD4 T cells preferentially migrate to the aorta and PaLN.

  • Permalink for 'Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype [IMMUNE REGULATION]' 22:00

    Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Adenosine targets both PKA and Epac pathways to suppress dendritic cell activation.

  • Adenosine/cAMP increases the expression of negative regulators of NF-B signaling.

  • Permalink for 'miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • miR-183C expression dynamically changes during iNKT cell development.

  • The deletion of miR-183C interferes with iNKT cell development and function.

  • Multiple target molecules are involved in miR-183C–mediated iNKT cell regulation.

  • Permalink for 'Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5 [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5 [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • 2F5 BCR B cells are tolerized primarily by reactivity to kynureninase, not lipid.

  • Extensive receptor editing occurs in 2F5 BCR knock-in mice.

  • Mature and anergic B cells often express identical BCRs in 2F5 knock-in mice.

  • Permalink for 'Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses [IMMUNOTHERAPY AND VACCINES]' 22:00

    Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • VLP enhances antinorovirus IgA recall responses in humanized mice.

  • Particulate structure is required for IgA enhancement.

  • VLP-driven IgA responses are functionally superior to IgG responses.

  • Permalink for 'Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 [IMMUNOTHERAPY AND VACCINES]' 22:00

    Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Live pertussis vaccine BPZE1 protects against B. pertussis infection within days.

  • Early protection induced by BPZE1 does not depend on adaptive immune responses.

  • Early protection induced by BPZE1 depends on TLR4-mediated innate immune responses.

  • Permalink for 'Pathogenic Role of an IL-23/{gamma}{delta}T17/Neutrophil Axis in Coxsackievirus B3-Induced Pancreatitis [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Pathogenic Role of an IL-23/{gamma}{delta}T17/Neutrophil Axis in Coxsackievirus B3-Induced Pancreatitis [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • CVB3 infection induces a transient IL-17A expression in the pancreas of mice.

  • Pancreatic IL-17A is mainly produced by V4 T cells.

  • IL-23/T17/neutrophil axis is critically involved in the onset of CVB3 pancreatitis.

  • Permalink for 'Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Chronic EtOH consumption alters the existing memory T cell compartment.

  • EtOH-induced changes in existing memory T cells increase susceptibility to IAV.

  • Chronic EtOH alters memory T cell–mediated killing and recruitment into the lungs.

  • Permalink for 'STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • An IBD genetic risk variant increases expression of both STAT3 and STAT5 in MDMs.

  • Inflammatory cytokines increase once STAT3/STAT5 expression falls below a threshold.

  • Various STAT3/STAT5-dependent inhibitory cytokines cooperate to reduce inflammation.

  • Permalink for 'Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Mice with sJIA show aberrant NK cell phenotype and defective NK cell cytotoxicity.

  • NK cells have a regulatory role in the development of sJIA disease.

  • NK cell defects are associated with more activated monocytes and dendritic cells.

  • Permalink for 'Staphylococcus aureus-Derived PSM{alpha} Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate {beta}-Arrestin Recruitment and Chemotaxis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Staphylococcus aureus-Derived PSM{alpha} Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate {beta}-Arrestin Recruitment and Chemotaxis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • FPR2-specific PSMα peptides are not chemotactic but activate the NADPH oxidase.

  • PSMα peptides induce ERK1/2 phosphorylation but not β-arrestin recruitment.

  • Permalink for 'IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • We established an exhaustive list of larval zebrafish ISGs.

  • Orthologous ISGs in fish and humans identify a large ancestral ISG repertoire.

  • Permalink for 'Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-{beta} [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-{beta} [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • The cleavage determinants of duSTING by NS2B3 are the R84 and G85 residues.

  • The interaction region is essential for the cleavage of duSTING by NS2B3.

  • Permalink for 'Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The β2m-free HLA-G1 isoform tends to dimerize and further multimerize.

  • The β2m-free HLA-G1 isoform specifically binds to LILRB2 with avidity effects.

  • The crystal structure of LILRB1/HLA-G1 complex showed a flexible binding manner.

  • Permalink for 'A TCR {beta}-Chain Motif Biases toward Recognition of Human CD1 Proteins [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    A TCR {beta}-Chain Motif Biases toward Recognition of Human CD1 Proteins [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TCR β variable gene 4-1 (TRBV4-1) is overrepresented among CD1b-specific T cells.

  • The association between TRBV4-1 usage and CD1b is independent of lipid Ag.

  • CD1b residue E80 is essential for binding of TRBV4-1–utilizing TCRs.

  • Permalink for 'Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells [MUCOSAL IMMUNOLOGY]' 22:00

    Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • NLRX1 activation induces immunometabolic mechanisms to reduce effector CD4+ T cells.

  • NX-13 is a novel NLRX1-targeting therapeutic for IBD.

  • NX-13 is effective in three mouse models of IBD and primary human cells from UC.

  • Permalink for 'Macrophages Are a Potent Source of Streptococcus-Induced IFN-{beta} [MUCOSAL IMMUNOLOGY]' 22:00

    Macrophages Are a Potent Source of Streptococcus-Induced IFN-{beta} [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Bone marrow GM-CSF culture gives rise to four distinct populations.

  • GM-CSF M can produce IFN-β.

  • GBS-stimulated GM-CSF M have the ability to adapt their phenotype to be more DC like.

  • Permalink for 'Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis [MUCOSAL IMMUNOLOGY]' 22:00

    Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Diet-induced obese mice exhibit reduced αβ and IEL persistence within 7 wk.

  • Obese mice are more susceptible to dextran sulfate sodium–induced colitis.

  • Diet-induced weight loss restores IEL number and improves outcome in colitis.

  • Permalink for 'A Novel Immunosuppressant, Luteolin, Modulates Alloimmunity and Suppresses Murine Allograft Rejection [TRANSPLANTATION]' 22:00

    A Novel Immunosuppressant, Luteolin, Modulates Alloimmunity and Suppresses Murine Allograft Rejection [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • Luteolin suppresses allograft rejection by regulating alloimmune responses.

  • Luteolin reduces effector T cell frequency while inducing CD4+Foxp3+ Tregs.

  • It also inhibits T cell proliferation by downregulating AKT/mTOR signaling.

  • Permalink for 'Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer [TUMOR IMMUNOLOGY]' 22:00

    Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Breast tumor MSC-derived exosomes elicit differentiation of M-MDSC to TAM.

  • MSC exosome–educated myeloid cells exacerbate immunosuppression in the breast TME.

  • In vivo PD-L1 blockade neutralizes MSC exosome–driven breast cancer progression.

  • Permalink for 'Correction: T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [CORRECTIONS]' 22:00

    Correction: T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [CORRECTIONS]

     » ‎ The Journal of Immunology
  • November 18, 2019
  • Permalink for 'Top Reads [TOP READS]' 22:00

    Top Reads [TOP READS]

     » ‎ The Journal of Immunology
  • Permalink for 'Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases [TRANSLATING IMMUNOLOGY]' 22:00

    Low-Dose IL-2 Therapy in Transplantation, Autoimmunity, and Inflammatory Diseases [TRANSLATING IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Inflammasomes: Their Role in Normal and Complicated Pregnancies [BRIEF REVIEWS]' 22:00

    Inflammasomes: Their Role in Normal and Complicated Pregnancies [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: TCR Signal Strength Regulates Acetyl-CoA Metabolism via AKT [CUTTING EDGE]' 22:00

    Cutting Edge: TCR Signal Strength Regulates Acetyl-CoA Metabolism via AKT [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • TCR signal strength regulates acetyl-CoA metabolism.

  • Weak TCR signals promote phosphorylation of citrate synthase via Akt.

  • TCR signal strength differentially regulates acetyl-lysine containing proteins.

  • Permalink for 'Inhibition of Allergic Reactivity through Targeting Fc{varepsilon}RI-Bound IgE with Humanized Low-Affinity Antibodies [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    Inhibition of Allergic Reactivity through Targeting Fc{varepsilon}RI-Bound IgE with Humanized Low-Affinity Antibodies [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • LARI inhibits allergic reactivity while displaying an excellent safety profile.

  • LARI blunts allergic responses via multiple mechanisms at multiple steps.

  • Permalink for 'Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity [AUTOIMMUNITY]' 22:00

    Malt1 Protease Deficiency in Mice Disrupts Immune Homeostasis at Environmental Barriers and Drives Systemic T Cell-Mediated Autoimmunity [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Autoreactive T cells drive the lethal disease in Malt1PD mice.

  • Malt1PD mice display B cell hyperactivation to environmental Ags.

  • IPEX-like disease occurs in Malt1PD mice despite in vitro Treg suppressive activity.

  • Permalink for 'cAMP Response Element Modulator {alpha} Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus [AUTOIMMUNITY]' 22:00

    cAMP Response Element Modulator {alpha} Induces Dual Specificity Protein Phosphatase 4 to Promote Effector T Cells in Juvenile-Onset Lupus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CREMα induces DUSP4 phosphatase expression in CD4+ T cells.

  • DUSP4 promotes IL-17A and reduces IL-2 production by effector T cells.

  • The CREMα/DUSP4 axis is involved in the pathophysiology of SLE.

  • Permalink for 'Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells [AUTOIMMUNITY]' 22:00

    Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CD11c+ ABCs exhibit functional characteristics of MBCs.

  • ABCs express polyreactive B cell receptors binding diverse self-antigens.

  • Adoptively transferred ABCs contribute to rapid recall responses to viral Ags.

  • Permalink for 'UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes [AUTOIMMUNITY]' 22:00

    UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • UBASH3A interacts with the TCR–CD3 complex and regulates its turnover.

  • UBASH3A facilitates the downmodulation of cell-surface TCR–CD3 upon TCR engagement.

  • UBASH3A binds to CBL-B, another T1D-associated protein that inhibits T cell function.

  • Permalink for 'TNF-Induced Interstitial Lung Disease in a Murine Arthritis Model: Accumulation of Activated Monocytes, Conventional Dendritic Cells, and CD21+/CD23- B Cell Follicles Is Prevented with Anti-TNF Therapy [AUTOIMMUNITY]' 22:00

    TNF-Induced Interstitial Lung Disease in a Murine Arthritis Model: Accumulation of Activated Monocytes, Conventional Dendritic Cells, and CD21+/CD23- B Cell Follicles Is Prevented with Anti-TNF Therapy [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • TNF-Tg mice develop NSIP-like lung disease with increased cDC2 and macrophages.

  • Anti-TNF therapy modulates prefibrotic ILD in TNF-Tg mice.

  • Permalink for 'Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of the Inflammatory Response [IMMUNE REGULATION]' 22:00

    Regulatory T Cell Transmigration and Intravascular Migration Undergo Mechanistically Distinct Regulation at Different Phases of the Inflammatory Response [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Regulatory T cells can undergo extensive intravascular crawling in skin vessels.

  • Mechanisms of regulatory T cell transmigration can be modulated dynamically.

  • Permalink for 'RELM{alpha} Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling [IMMUNE REGULATION]' 22:00

    RELM{alpha} Licenses Macrophages for Damage-Associated Molecular Pattern Activation to Instigate Pulmonary Vascular Remodeling [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RELMα (hResistin) activates pulmonary macrophages in PAH patients and hypoxic mice.

  • RELMα (hResistin) induces HMGB1 acetylation by suppressing Sirt1 in macrophages.

  • The RELMα–HMGB1 axis causes macrophage-mediated PASMC proliferation.

  • Permalink for 'TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity [IMMUNE REGULATION]' 22:00

    TLR2 Stimulation Increases Cellular Metabolism in CD8+ T Cells and Thereby Enhances CD8+ T Cell Activation, Function, and Antiviral Activity [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • TLR2 directly regulates the anti-CD3–activated CD8+ T cells independently on APCs.

  • Bioenergy metabolism is important for TLR2-mediated enhancement of CD8+ T cells.

  • TLR2 enhances the antiviral CD8+ T cell response and the efficacy of HBV vaccine.

  • Permalink for 'Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206+ Dendritic Cells to Skin-Draining Lymph Nodes [IMMUNE REGULATION]' 22:00

    Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206+ Dendritic Cells to Skin-Draining Lymph Nodes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • MHCII molecule upregulation is not required for the development of skin moDCs.

  • Skin CD206+ moDCs do not migrate to LNs in the absence of MHCII ubiquitination.

  • GM-CSF restores the migration of skin moDCs by upregulating CCR7 and IRF4.

  • Permalink for 'Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3 [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3 [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Fnip1 is required for pre–B cell development/survival independent of p53 and Bcl-xL.

  • Fnip1 is required for optimal inhibition of mTORC1 in response to amino acid restriction.

  • Fnip1 regulates TFE3 nuclear translocation and lysosome biogenesis in pre–B cells.

  • Permalink for 'Ancient BCMA-like Genes Herald B Cell Regulation in Lampreys [IMMUNOGENETICS]' 22:00

    Ancient BCMA-like Genes Herald B Cell Regulation in Lampreys [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • Two lamprey BCMA-like receptors interact with a single lamprey BAFF protein.

  • BCMAL1 and BCMAL2 genes are differentially expressed during VLRB cell stimulation.

  • BAFF-based mechanisms for B cell regulation appeared early in vertebrate evolution.

  • Permalink for 'MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria [IMMUNOTHERAPY AND VACCINES]' 22:00

    MR1-Independent Activation of Human Mucosal-Associated Invariant T Cells by Mycobacteria [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • MAIT cells comprise half the CD8 T cell IFN- response to BCG in blood.

  • Frequencies of MAIT cells were not sustainably modulated by BCG vaccination.

  • Innate cytokines mediate BCG-induced MAIT cell responses in whole blood.

  • Permalink for 'Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Role of IL-15 Signaling in the Pathogenesis of Simian Immunodeficiency Virus Infection in Rhesus Macaques [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Anti–IL-15 depletes NK cells and disrupts TEM homeostasis in SIV-infected RM.

  • IL-15 inhibition does not alter SIV replication dynamics or CD4+ T cell depletion.

  • IL-15 inhibition does accelerate reactivation of an oncogenic -herpesvirus.

  • Permalink for 'The IL-12- and IL-23-Dependent NK Cell Response Is Essential for Protective Immunity against Secondary Toxoplasma gondii Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    The IL-12- and IL-23-Dependent NK Cell Response Is Essential for Protective Immunity against Secondary Toxoplasma gondii Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • NK cells are required for immune control of secondary T. gondii infection.

  • NK cells do not develop intrinsic memory-like features during T. gondii infection.

  • Secondary NK cell responses depend upon IL-12 and IL-23.

  • Permalink for 'Multiple Signaling Pathways Involved in Human Dendritic Cell Maturation Are Affected by the Fungal Quorum-Sensing Molecule Farnesol [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Multiple Signaling Pathways Involved in Human Dendritic Cell Maturation Are Affected by the Fungal Quorum-Sensing Molecule Farnesol [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • FOH promotes CD1d expression in human DC via activation of PPAR, RARα, and p38 MAPK.

  • FOH modulates cytokine release through nuclear receptors, MAPK, and NF-B pathways.

  • FOH diminishes human DC capacity to activate iNKT, Th1, and FOXP3+ regulatory T cells.

  • Permalink for 'The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • DR3 is highly expressed on human MAIT cells.

  • DR3 ligand TL1A licenses innate TNF-α production and boosts polyfunctionality.

  • TL1A equally augments TCR-dependent MAIT cell effector functions.

  • Permalink for 'Long-Term Microgliosis Driven by Acute Systemic Inflammation [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Long-Term Microgliosis Driven by Acute Systemic Inflammation [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Early monocyte infiltration causes long-term microgliosis in sepsis.

  • Brain microglia self-proliferate during severe sepsis.

  • Microglia proliferation is associated with local M-CSF.

  • Permalink for 'Glycogen Synthase Kinase 3{beta} Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Glycogen Synthase Kinase 3{beta} Regulates Antiviral Responses of TLR3 via TRAF2-Src Axis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • GSK3β interacts with Src tyrosine kinase.

  • Src positively regulates antiviral immune response.

  • Src undergoes K63-linked ubiquitination by TRAF2.

  • Permalink for 'A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Pseudomonas bacterial lung infection leads to pulmonary ACE2 dynamic variation.

  • The ACE2 dynamic alteration is critical in regulating neutrophilic lung inflammation.

  • ACE2 modulates IL-17–mediated neutrophil influx by impacting STAT3 activity.

  • Permalink for 'Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Exercise Promotes Resolution of Acute Inflammation by Catecholamine-Mediated Stimulation of Resolvin D1 Biosynthesis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Exercise enhances resolution of acute inflammation and RvD1 biosynthesis.

  • Epinephrine stimulates macrophage production of RvD1 through α1-AR.

  • α1-AR blockade in vivo abrogates exercise-enhanced resolution.

  • Permalink for 'Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Ubc9 Interacts with and SUMOylates the TCR Adaptor SLP-76 for NFAT Transcription in T Cells [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Ubc9 interacts with and SUMOylates the immune adaptor SLP-76 in T cells.

  • Synergy of SLP-76–Ubc9 on IL-2 transcription is SLP-76 SUMOylation dependent.

  • SLP-76 SUMOylation is required for Ubc9-NFAT complex assembly for IL-2 transcription.

  • Permalink for 'Recognition of Lewis X by Anti-Lex Monoclonal Antibody IG5F6 [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Recognition of Lewis X by Anti-Lex Monoclonal Antibody IG5F6 [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Recognition of monomeric Lex by IG5F6 using a panel of Lex analogues was studied.

  • Anti-Lex mAbs bind in different ways; the hydrophobic patch of β-d-Gal is essential.

  • Permalink for 'Uhrf1-Mediated Tnf-{alpha} Gene Methylation Controls Proinflammatory Macrophages in Experimental Colitis Resembling Inflammatory Bowel Disease [MUCOSAL IMMUNOLOGY]' 22:00

    Uhrf1-Mediated Tnf-{alpha} Gene Methylation Controls Proinflammatory Macrophages in Experimental Colitis Resembling Inflammatory Bowel Disease [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Uhrf1-mediated DNA methylation represses Tnf-α expression in macrophages.

  • Uhrf1 deficiency augments Tnf-α expression, resulting in aggravated colitis.

  • Tnf-α triggers macrophage activation through destabilizing Uhrf1 protein.

  • Permalink for 'Pharyngeal Immunity in Early Vertebrates Provides Functional and Evolutionary Insight into Mucosal Homeostasis [MUCOSAL IMMUNOLOGY]' 22:00

    Pharyngeal Immunity in Early Vertebrates Provides Functional and Evolutionary Insight into Mucosal Homeostasis [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • A mucosally associated lymphoid tissue is identified in teleost pharyngeal cavity.

  • Trout pharyngeal bacteria are mainly coated with secretory IgT.

  • Teleost IgT plays a vital role in protecting the PC from invading pathogens.

  • Permalink for 'Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of Intestinal Tissue Homeostasis [MUCOSAL IMMUNOLOGY]' 22:00

    Dendritic Cells Control Regulatory T Cell Function Required for Maintenance of Intestinal Tissue Homeostasis [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Inhibitory receptors are upregulated on peripheral Tregs of DC-deficient mice.

  • Tregs from DC-deficient mice are functionally impaired.

  • Tregs require DCs for inhibition of T cell transfer-induced colitis.

  • Permalink for 'STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage [TUMOR IMMUNOLOGY]' 22:00

    STAT3-Induced Wnt5a Provides Chronic Lymphocytic Leukemia Cells with Survival Advantage [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • STAT3 induces the expression of Wnt5a in CLL cells.

  • Wnt5a provides CLL cells with survival advantage.

  • November 04, 2019
  • Permalink for 'Top Reads [TOP READS]' 22:00

    Top Reads [TOP READS]

     » ‎ The Journal of Immunology
  • Permalink for 'Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology [BRIEF REVIEWS]' 22:00

    Tissue-Resident Memory T Cells in Mice and Humans: Towards a Quantitative Ecology [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life [CUTTING EDGE]' 22:00

    Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Neonatal CD8+ T cells exhibit a bias for glycolytic metabolism postinfection.

  • Higher glycolytic activity in neonatal CD8+ T cells is related to Lin28b expression.

  • Inhibiting glycolysis restores the formation of neonatal memory CD8+ T cells.

  • Permalink for 'High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    High GILT Expression and an Active and Intact MHC Class II Antigen Presentation Pathway Are Associated with Improved Survival in Melanoma [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • High GILT mRNA expression is associated with improved overall survival in melanoma.

  • IFN-, TNF-α and IL-1β induce GILT expression in melanocytes.

  • An active and intact MHC class II pathway correlates with improved melanoma survival.

  • Permalink for 'Peroxisome Proliferator-Activated Receptor-{delta} Acts within Peripheral Myeloid Cells to Limit Th Cell Priming during Experimental Autoimmune Encephalomyelitis [AUTOIMMUNITY]' 22:00

    Peroxisome Proliferator-Activated Receptor-{delta} Acts within Peripheral Myeloid Cells to Limit Th Cell Priming during Experimental Autoimmune Encephalomyelitis [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Deficiency of PPAR- in peripheral myeloid cells enhances EAE severity.

  • Deficiency of PPAR- increases production of IL-12p40 homodimer by dendritic cells.

  • Permalink for 'RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells [IMMUNE REGULATION]' 22:00

    RelB Deficiency in Dendritic Cells Protects from Autoimmune Inflammation Due to Spontaneous Accumulation of Tissue T Regulatory Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RelB deficiency in dendritic cells leads to accumulation of tissue Tregs.

  • Treg accumulation occurs independent of IL-33 and at the expense of ROR(t)+ Tregs.

  • Tissue Treg accumulation protects from experimental autoimmune encephalomyelitis.

  • Permalink for 'Activation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients [IMMUNE REGULATION]' 22:00

    Activation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • OX40 was highly expressed on MAIT cells of T2D patients.

  • OX40-positive MAIT cells showed high activation and a memory phenotype.

  • Activated OX40 signaling promoted caspase-3 activation and apoptosis of MAIT cells.

  • Permalink for '{gamma}{delta} T Cell-Secreted XCL1 Mediates Anti-CD3-Induced Oral Tolerance [IMMUNE REGULATION]' 22:00

    {gamma}{delta} T Cell-Secreted XCL1 Mediates Anti-CD3-Induced Oral Tolerance [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Oral anti-CD3 induces gut lamina propria T cells to produce XCL1.

  • XCL1-activated CCR7+XCR1+ cDCs migrate to the mLN.

  • In the mLN, Treg cells are induced and oral tolerance is established.

  • Permalink for 'Crlz-1 Controls Germinal Center Reaction by Relaying a Wnt Signal to the Bcl-6 Expression in Centroblasts during Humoral Immune Responses [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Crlz-1 Controls Germinal Center Reaction by Relaying a Wnt Signal to the Bcl-6 Expression in Centroblasts during Humoral Immune Responses [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Crlz-1 relays a Wnt3a signal to the Bcl-6 expression in the centroblast during GC reaction.

  • Crlz-1 mobilizes CBFβ into the nucleus to allow Runx/CBFβ binding to the Bcl-6 promoter.

  • The Wnt/Crlz-1/CBFβ/Bcl-6 regulatory axis controls the centroblastic proliferation of GC.

  • Permalink for 'STAT3 Inhibition Partly Abolishes IL-33-Induced Bone Marrow-Derived Monocyte Phenotypic Transition into Fibroblast Precursor and Alleviates Experimental Renal Interstitial Fibrosis [IMMUNOTHERAPY AND VACCINES]' 22:00

    STAT3 Inhibition Partly Abolishes IL-33-Induced Bone Marrow-Derived Monocyte Phenotypic Transition into Fibroblast Precursor and Alleviates Experimental Renal Interstitial Fibrosis [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • IL-33 induces phenotypic transition of monocytes into fibrocytes in vitro.

  • Phenotypic monocyte-to-fibrocyte transition is increased in renal fibrosis.

  • STAT3 inhibition partly abolishes the increased monocyte phenotypic transition.

  • Permalink for 'IL-36{gamma} Is a Key Regulator of Neutrophil Infiltration in the Vaginal Microenvironment and Limits Neuroinvasion in Genital HSV-2 Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    IL-36{gamma} Is a Key Regulator of Neutrophil Infiltration in the Vaginal Microenvironment and Limits Neuroinvasion in Genital HSV-2 Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • IL-36 is crucial for neutrophil recruitment in response to genital HSV-2 infection.

  • Genital HSV-2 disease pathogenesis progresses more rapidly in IL-36–/– mice.

  • IL-36–/– mice exhibit significantly increased HSV-2 neuroinvasion and virus spread.

  • Permalink for 'Mycobacterium tuberculosis LprE Suppresses TLR2-Dependent Cathelicidin and Autophagy Expression to Enhance Bacterial Survival in Macrophages [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Mycobacterium tuberculosis LprE Suppresses TLR2-Dependent Cathelicidin and Autophagy Expression to Enhance Bacterial Survival in Macrophages [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Mycobacterium tuberculosis LprE aids intercellular bacterial survival.

  • LprE suppress cathelicidin and autophagy expression in macrophages.

  • LprE regulates immune responses through TLR2.

  • Permalink for 'Distinct Host-Mycobacterial Pathogen Interactions between Resistant Adult and Tolerant Tadpole Life Stages of Xenopus laevis [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Distinct Host-Mycobacterial Pathogen Interactions between Resistant Adult and Tolerant Tadpole Life Stages of Xenopus laevis [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Xenopus tadpoles and adults have adapted distinct immune responses to mycobacteria.

  • Disease tolerance involves a noninflammatory iT cell response in tadpoles.

  • Disease resistance involves granuloma, inflammation, and CD8 T cell response in adults.

  • Permalink for 'The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Kupffer cell depletion leads to enhanced lipolysis in adipose tissue.

  • Kupffer cells inhibit hepatocyte FGF21 expression through IL-1β.

  • Kupffer cells regulate adipose tissue lipolysis through FGF21.

  • Permalink for 'The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Second Receptor for C5a, C5aR2, Is Detrimental to Mice during Systemic Infection with Listeria monocytogenes [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • C5aR2 is detrimental to the host immune response to early L. monocytogenes infection.

  • C5aR2 suppresses NF-B–mediated expression of IFN-.

  • C5aR2 acts as a decoy receptor for C5aR1-mediated inhibition of IFN-β expression.

  • Permalink for 'Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Gasdermin D Drives the Nonexosomal Secretion of Galectin-3, an Insulin Signal Antagonist [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Galectin-3 is discovered to be an inflammasome effector desensitizing insulin signaling.

  • GSDMD perforates the plasma membrane for nonexosomal secretion of galectin-3.

  • The inflammasome–galectin-3 axis exacerbates insulin resistance in vivo.

  • Permalink for 'Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung [MUCOSAL IMMUNOLOGY]' 22:00

    Inflammasome-Independent Role for NLRP3 in Controlling Innate Antihelminth Immunity and Tissue Repair in the Lung [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Nlrp3–/– mice have enhanced early antihelminth immunity in the lung.

  • Type 2 immunity and repair responses are dysregulated in Nlrp3–/– mice.

  • NLRP3 plays an inflammasome-independent role during Nippostrongylus infection.

  • Permalink for 'The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice [TUMOR IMMUNOLOGY]' 22:00

    The Tumor-Immune Response Is Not Compromised by Mesenchymal Stromal Cells in Humanized Mice [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Engineered fibroblastic tumors are efficiently recognized in humanized mice.

  • hUC-MSCs have a negligible impact on tumor-immune infiltration and growth.

  • hUC-MSCs have no effect on tumor growth independently of the injection site.

  • October 21, 2019
  • Permalink for 'Top Reads [TOP READS]' 22:00

    Top Reads [TOP READS]

     » ‎ The Journal of Immunology
  • Permalink for 'Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells" [LETTERS TO THE EDITOR]' 22:00

    Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells" [LETTERS TO THE EDITOR]

     » ‎ The Journal of Immunology
  • Permalink for 'Response to Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells" [LETTERS TO THE EDITOR]' 22:00

    Response to Comment on "Identification of an Intronic Regulatory Element Necessary for Tissue-Specific Expression of Foxn1 in Thymic Epithelial Cells" [LETTERS TO THE EDITOR]

     » ‎ The Journal of Immunology
  • Permalink for 'Platelets in Inflammation and Resolution [BRIEF REVIEWS]' 22:00

    Platelets in Inflammation and Resolution [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Detection of Cell Surface Ligands for Human Synovial {gamma}{delta} T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Detection of Cell Surface Ligands for Human Synovial {gamma}{delta} T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TCR- tetramer identified ligand expression by flow cytometry.

  • TCR- ligands were induced on activated monocytes or T cells.

  • Bioinformatics combined with mass spectrometry produced an overlapping list of 16 candidate ligands.

  • Permalink for 'In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance [IMMUNE REGULATION]' 22:00

    In Vivo Function of the Lipid Raft Protein Flotillin-1 during CD8+ T Cell-Mediated Host Surveillance [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Flot1–/– CD8+ T cells have altered cell morphology and speeds in vivo.

  • Flot1–/– CD8+ T cells show robust expansion and infiltration of peripheral tissues.

  • Permalink for 'The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-{beta} Signaling in CD4+ T Cells to Facilitate Foxp3+ Regulatory T and TH17 Cell Differentiation [IMMUNE REGULATION]' 22:00

    The Deubiquitinating Enzyme Ubiquitin-Specific Peptidase 11 Potentiates TGF-{beta} Signaling in CD4+ T Cells to Facilitate Foxp3+ Regulatory T and TH17 Cell Differentiation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • The mRNA encoding for USP11 is preferentially translated in TREG cells.

  • USP11 modulates TGF-β signaling in murine CD4+ T cells.

  • The USP11/TGF-β axis favors TREG and TH17 cell development.

  • Permalink for 'Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture [IMMUNE REGULATION]' 22:00

    Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Mice lacking Grk2 B cell expression develop a severe immune phenotype.

  • Grk2 expression in B cells limits S1PR1 signaling but augments CXCR5 signaling.

  • An S1PR1 antagonist partially normalizes the signaling defects and immune phenotypes.

  • Permalink for 'TNF-{alpha} Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection [IMMUNE REGULATION]' 22:00

    TNF-{alpha} Contributes to Lymphoid Tissue Disorganization and Germinal Center B Cell Suppression during Intracellular Bacterial Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • E. muris infection causes major changes in spleen morphology.

  • The changes in lymphoid tissue organization were in part due to TNF-α.

  • Neutralization of TNF-α resulted in an increase in GC-phenotype T-bet+ B cells.

  • Permalink for 'BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish [IMMUNOGENETICS]' 22:00

    BTLA-HVEM Checkpoint Axis Regulates Hepatic Homeostasis and Inflammation in a ConA-Induced Hepatitis Model in Zebrafish [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • BTLA–HVEM checkpoint axis regulates hepatic homeostasis and inflammation.

  • Engagement of BTLA by HVEM triggers inhibitory signals for CD8+ T cell tolerization.

  • A potential BTLA–HVEM–LIGHT modulatory network is involved in hepatitis.

  • Permalink for 'Topical Adjuvant Application during Subcutaneous Vaccination Promotes Resident Memory T Cell Generation [IMMUNOTHERAPY AND VACCINES]' 22:00

    Topical Adjuvant Application during Subcutaneous Vaccination Promotes Resident Memory T Cell Generation [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Topical CpG adjuvant with s.c. Ag vaccination promotes skin CD8 TRM.

  • Topical CpG adjuvant activity depends on TLR9 expression by hematopoietic cells.

  • Topical CpG adjuvant promotes global protection against dermal tumor challenge.

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