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The Journal of Immunology (100 unread)

 
  • Permalink for 'Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling [CUTTING EDGE]' 22:00

    Cutting Edge: USP27X Deubiquitinates and Stabilizes the DNA Sensor cGAS to Regulate Cytosolic DNA-Mediated Signaling [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • USP27X promotes deubiquitination and stabilization of cGAS.

  • USP27X deficiency impairs cGAS-mediated innate signaling.

  • USP27X positively regulates innate antiviral immunity to DNA viruses.

  • Permalink for 'Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V{kappa}8 B Cells [AUTOIMMUNITY]' 22:00

    Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 V{kappa}8 B Cells [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • The AM14 V8 BCR recognizes a B6-derived cross-reactive Ag.

  • This B6 self-antigen induces anergy, receptor editing, and MZ B cell development.

  • Anergic AM14 V8 B cells can be fully activated by nucleic acid containing ICs.

  • Permalink for 'Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Early KLRG1+ but Not CD57+CD8+ T Cells in Primary Cytomegalovirus Infection Predict Effector Function and Viral Control [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • We report (to our knowledge) novel CMV-specific KLRG1+CD27+ CD57+/– CD8+ TAEFF in primary infection.

  • KLRG1+ TAEFF correlates with CMV function and control in lung transplant patients.

  • Permalink for 'Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Reduced GPx4 and increased lipid peroxidation are exhibited in IPF lung fibroblasts.

  • Lipid peroxidation is involved in lung fibrosis development through TGF-β signaling.

  • GPx4-regulated lipid peroxidation can be a therapeutic target for IPF.

  • Permalink for 'IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • IL-10 inhibition increases T cell IFN- and monocyte TNF-α in septic patients.

  • rhIL-10 increases T cell production of IFN- in septic patient PBMCs.

  • rhIL-10 decreases monocyte TNF-α production and HLA-DR expression in sepsis.

  • Permalink for 'Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Dissection of the Effects of JAK and BTK Inhibitors on the Functionality of Healthy and Malignant Lymphocytes [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • JAK inhibitors momelotinib and ruxolitinib show differential effects on CLL cells.

  • JAK inhibitors may be a promising addition for CLL therapy.

  • Permalink for 'CD24hiCD38hi and CD24hiCD27+ Human Regulatory B Cells Display Common and Distinct Functional Characteristics [IMMUNE REGULATION]' 22:00

    CD24hiCD38hi and CD24hiCD27+ Human Regulatory B Cells Display Common and Distinct Functional Characteristics [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • CD24hiCD27+ Bregs and TBs represent major Bregs in humans.

  • CD24hiCD27+ Bregs express IL-10 and increased levels of granzyme B and TGFβ1.

  • CD24hiCD27+ Bregs are more efficient than TBs at suppressing T cell responses.

  • Permalink for 'IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes [IMMUNE REGULATION]' 22:00

    IgM, IgG, and IgA Influenza-Specific Plasma Cells Express Divergent Transcriptomes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • A fix/permeabilization approach allows isolation of Ag- and isotype-specific ASC.

  • IgM, IgG, and IgA ASC have shared and distinct transcriptome components.

  • Each ASC isotype displays distinct, expanded CDR3 regions.

  • Permalink for 'Regulatory Macrophages Inhibit Alternative Macrophage Activation and Attenuate Pathology Associated with Fibrosis [IMMUNE REGULATION]' 22:00

    Regulatory Macrophages Inhibit Alternative Macrophage Activation and Attenuate Pathology Associated with Fibrosis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RMs inhibit alternative M activation.

  • Inhibition of alternate activation by RMs was not entirely dependent on IL-10.

  • RM attenuated alternative activated M-mediated pathological conditions in peritoneal fibrosis.

  • Permalink for 'Identification of a Novel Role for Foxo3 Isoform2 in Osteoclastic Inhibition [IMMUNE REGULATION]' 22:00

    Identification of a Novel Role for Foxo3 Isoform2 in Osteoclastic Inhibition [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • This study reveals the first (to our knowledge) known biological function of Foxo3 isoform2 in bone.

  • Foxo3 isoform2 is an activator for IFN-I response and an osteoclastic inhibitor.

  • Foxo3 isoform2 mice exclusively expressing isoform2 show osteopetrosis phenotype.

  • Permalink for 'Distinct PLZF+CD8{alpha}{alpha}+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity [IMMUNE REGULATION]' 22:00

    Distinct PLZF+CD8{alpha}{alpha}+ Unconventional T Cells Enriched in Liver Use a Cytotoxic Mechanism to Limit Autoimmunity [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • PLZF expression in CD8αα Tunc distinguishes them from conventional CD8 T cells.

  • CD8αα Tunc express NK cell markers and are dependent upon IL-2Rβ signaling.

  • CD8αα Tunc use perforin in a negative feedback mechanism to control autoimmunity.

  • Permalink for 'Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77 [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Glucocorticoids Oppose Thymocyte Negative Selection by Inhibiting Helios and Nur77 [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Thymocyte GR deficiency enhances Ag-specific negative selection.

  • GCs antagonize negative selection by repressing Helios and Nur77 expression.

  • Permalink for 'Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Progranulin Decreases Susceptibility to Streptococcus pneumoniae in Influenza and Protects against Lethal Coinfection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • PGRN decreases postinfluenza susceptibility to S. pneumoniae coinfection in mice.

  • PGRN increases survival of mice in lethal influenza/S. pneumoniae coinfection.

  • PGRN suppresses lung inflammation and ERS-mediated apoptosis in coinfection.

  • Permalink for 'Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Helicobacter pylori Exploits the NLRC4 Inflammasome to Dampen Host Defenses [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • H. pylori induces IL-18 through the NLRC4 inflammasome in gastric epithelial cells.

  • IL-18 blocks β-defensin 1 expression via NF-B activation.

  • NLRC4 contributes to H. pylori immunoescape.

  • Permalink for 'Mycobacterium tuberculosis-Induced Bronchoalveolar Lavage Gene Expression Signature in Latent Tuberculosis Infection Is Dominated by Pleiotropic Effects of CD4+ T Cell-Dependent IFN-{gamma} Production despite the Presence of Polyfunctional T Cells within' 22:00

    Mycobacterium tuberculosis-Induced Bronchoalveolar Lavage Gene Expression Signature in Latent Tuberculosis Infection Is Dominated by Pleiotropic Effects of CD4+ T Cell-Dependent IFN-{gamma} Production despite the Presence of Polyfunctional T Cells within

     » ‎ The Journal of Immunology
  • IFN- dominates the CD4+-dependent M. tuberculosis–induced BAL cell gene signature in LTBI.

  • Nevertheless, CD4+ BAL cells in LTBI display polyfunctional responses to M. tuberculosis.

  • This signature may provide a means to assess vaccine-induced local immunity to M. tuberculosis.

  • Permalink for 'Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R- Transcriptional Signature Express Fc{gamma}RIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Terminal Effector CD8 T Cells Defined by an IKZF2+IL-7R- Transcriptional Signature Express Fc{gamma}RIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific Antibody-Dependent Cellular Cytotoxicity [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Chronic HIV-1 is associated with increased levels of FcRIIIA+ CD8 T cells.

  • FcRIIIA+ CD8 T cells display an innate transcriptomic profile akin to NK cells.

  • ADCC is mediated by FcRIIIA+ CD8 T cells at levels comparable with NK cells.

  • Permalink for 'miR-301a Regulates Inflammatory Response to Japanese Encephalitis Virus Infection via Suppression of NKRF Activity [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    miR-301a Regulates Inflammatory Response to Japanese Encephalitis Virus Infection via Suppression of NKRF Activity [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • JEV infection elicits miR-301a upregulation in microglial cells.

  • miR-301a upregulation reduces NKRF abundance, thus amplifying NF-B signaling.

  • Inhibiting miR-301a reduces microglia-mediated bystander killing of neurons.

  • Permalink for 'Glutathione Reductase Promotes Fungal Clearance and Suppresses Inflammation during Systemic Candida albicans Infection in Mice [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Glutathione Reductase Promotes Fungal Clearance and Suppresses Inflammation during Systemic Candida albicans Infection in Mice [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Gsr–/– mice exhibited markedly increased susceptibility to C. albicans challenge.

  • Gsr–/– neutrophils display defects in fungicidal activity.

  • Gsr–/– macrophages exhibit an enhanced inflammatory response.

  • Permalink for 'Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to Mycobacterium tuberculosis Infection [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Identification of an Increased Alveolar Macrophage Subpopulation in Old Mice That Displays Unique Inflammatory Characteristics and Is Permissive to Mycobacterium tuberculosis Infection [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • This study identified two distinct alveolar macrophage populations in old mice.

  • A CD11c+ CD11b alveolar macrophage population is immune regulatory.

  • CD11c+ CD11b+ macrophages are more inflammatory and permissive for M. tuberculosis.

  • Permalink for 'IL-37 Attenuates Lung Fibrosis by Inducing Autophagy and Regulating TGF-{beta}1 Production in Mice [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    IL-37 Attenuates Lung Fibrosis by Inducing Autophagy and Regulating TGF-{beta}1 Production in Mice [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • IL-37 is expressed in alveolar epithelial cells and macrophages.

  • IL-37 levels are decreased in lung and blood obtained from IPF patients.

  • IL-37 attenuates lung fibrosis by inducing autophagy and inhibiting TGF-β1 signaling.

  • Permalink for 'Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • LL-37 antimicrobial peptides promote macrophage uptake of NETs.

  • NETs modulate LPS-induced cytokine responses in macrophages and DCs.

  • NETs are digested intra- and extracellularly by TREX1 and DNase1L3.

  • Permalink for 'The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The Role of TTP Phosphorylation in the Regulation of Inflammatory Cytokine Production by MK2/3 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • MK2/3 are the only LPS-induced kinases for S52 and S178 of TTP.

  • TNF regulation by MK2/3 is not restricted to TTP phosphorylation at S52 and S178.

  • The MK2/3/TTP signaling axis contributes to sepsis in vivo.

  • Permalink for 'KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    KIR Polymorphism Modulates the Size of the Adaptive NK Cell Pool in Human Cytomegalovirus-Infected Individuals [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • KIR polymorphism crucially influences NK cell responses to HCMV.

  • The size of NKG2C expansions correlates with loss of KIR repertoire diversity.

  • These NKG2C expansions correlated with the HCMV-specific Ab concentration.

  • Permalink for 'A Hint of Primitive Mucosal Immunity in Shrimp through Marsupenaeus japonicus Gill C-Type Lectin [MUCOSAL IMMUNOLOGY]' 22:00

    A Hint of Primitive Mucosal Immunity in Shrimp through Marsupenaeus japonicus Gill C-Type Lectin [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • MjGCTL provides functional evidence of immune defense in shrimp gills.

  • Gill defense by MjGCTL reveals primitive mucosal immunity in shrimp.

  • Permalink for 'IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology [MUCOSAL IMMUNOLOGY]' 22:00

    IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • IL-25 contributes to specific disease phenotypes in chronic HDM-induced asthma.

  • Lung remodeling is partly dependent on IL-25 signaling in cDCs and in Th cells.

  • IL-25 induces clustering of Th9 T cells next to IL-25–activated cDCs in airways.

  • Permalink for 'T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4+ T Regulatory Cell Activity In Vivo following Transplantation [TRANSPLANTATION]' 22:00

    T Cell-Specific Adaptor Protein Regulates Mitochondrial Function and CD4+ T Regulatory Cell Activity In Vivo following Transplantation [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • TSAd knockout mice mount accelerated rejection responses following transplantation.

  • TSAd is a potent regulator of cellular activation in CD4+ Tregs.

  • TSAd knockout CD4+ Tregs fail to shuttle Lck from the cytoplasm to mitochondria.

  • Permalink for 'Lymphatic Cannulation for Lymph Sampling and Molecular Delivery [NOVEL IMMUNOLOGICAL METHODS]' 22:00

    Lymphatic Cannulation for Lymph Sampling and Molecular Delivery [NOVEL IMMUNOLOGICAL METHODS]

     » ‎ The Journal of Immunology
  • Lymph carries the "omic," vesicular, and immune cell signature of the draining organs.

  • Lymph analysis provides precise and "undiluted" biochemical and cellular information.

  • A protocol for lymph collection from mouse and rat lymphatics is reported.

  • September 24, 2019
  • Permalink for 'Henry Metzger, M.D. (1932-2018), The American Association of Immunologists President, 1991-1992 [IN MEMORIAM]' 19:38

    Henry Metzger, M.D. (1932-2018), The American Association of Immunologists President, 1991-1992 [IN MEMORIAM]

     » ‎ The Journal of Immunology
  • Permalink for 'In This Issue [IN THIS ISSUE]' 19:38

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State [PILLARS OF IMMUNOLOGY]' 19:38

    The Colon as a Major Site of Immunoregulation by CD4+ T Cell Subsets in the Steady State [PILLARS OF IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships [CUTTING EDGE]' 19:38

    Cutting Edge: Ig H Chains Are Sufficient to Determine Most B Cell Clonal Relationships [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • More than 80% of H chain–based clones contained cells expressing consistent L chains.

  • L chain junction diversity did not further refine these H chain–based clones.

  • Leveraging additional H chain features could improve B cell clonal inference.

  • Permalink for 'Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies [ALLERGY AND OTHER HYPERSENSITIVITIES]' 19:38

    Interplay between Affinity and Valency in Effector Cell Degranulation: A Model System with Polcalcin Allergens and Human Patient-Derived IgE Antibodies [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Human-derived IgE and allergens were used to study IgE-mediated cellular activation.

  • Multivalent allergens can effectively cross-link low-affinity IgE–FcRI complexes.

  • Epitope orientation and spacing can improve IgE–FcRI cross-linking.

  • Permalink for 'A Mast Cell-Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion [ALLERGY AND OTHER HYPERSENSITIVITIES]' 19:38

    A Mast Cell-Specific Receptor Is Critical for Granuloma Induced by Intrathecal Morphine Infusion [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • A mouse model of granuloma induced by intrathecal morphine was established.

  • Mast cell–specific receptor MrgprB2 is essential for granuloma pathogenesis.

  • Activation of MrgprB2 in mast cells promote granuloma-related cell recruitment.

  • Permalink for 'Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs [ANTIGEN RECOGNITION AND RESPONSES]' 19:38

    Targeting Antigens to CD180 but Not CD40 Programs Immature and Mature B Cell Subsets to Become Efficient APCs [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • CD180 Ag targeting facilitates Ag presentation by B cells to CD4+ T cells.

  • Immature B cells are sufficient for TFH cell maturation.

  • Compared with CD180, CD40 targeting induces slower and lower-affinity IgG responses.

  • Permalink for 'Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules [ANTIGEN RECOGNITION AND RESPONSES]' 19:38

    Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • UCH-L1 expression and activity in DCs are regulated by immune stimuli.

  • Cross-priming of the CD8 T cell response is affected by UCH-L1.

  • MHC I recycling for cross-presentation is promoted by UCH-L1.

  • Permalink for 'Pregnancy Enables Expansion of Disease-Specific Regulatory T Cells in an Animal Model of Multiple Sclerosis [AUTOIMMUNITY]' 19:38

    Pregnancy Enables Expansion of Disease-Specific Regulatory T Cells in an Animal Model of Multiple Sclerosis [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • EAE but not pregnancy increases TCRβ clonality in Tcon and Treg.

  • Pregnancy is required for expansion of TRBV13-2–positive Treg.

  • Pregnancy is required for expansion of EAE-related Treg clonotypes.

  • Permalink for 'Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients [AUTOIMMUNITY]' 19:38

    Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Annexin A1 expression is reduced in T cells from naive-to-treatment RRMS subjects.

  • Annexin A1 levels correlate inversely with disease clinical score.

  • Annexin A1 reduces T cell activation, proliferation, and glycolysis.

  • Permalink for 'Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors [AUTOIMMUNITY]' 19:38

    Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Increased mTNF and defect in M2-like macrophages are biomarkers specific to RA.

  • Increase in miR155 is responsible for this defect and could be a new target for therapeutic strategies.

  • Permalink for 'Immunoproteasome Inhibition Selectively Kills Human CD14+ Monocytes and as a Result Dampens IL-23 Secretion [AUTOIMMUNITY]' 19:38

    Immunoproteasome Inhibition Selectively Kills Human CD14+ Monocytes and as a Result Dampens IL-23 Secretion [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CD14+ monocytes are the main producers of IL-23 in LPS-stimulated human PBMCs.

  • Immunoproteasome inhibition selectively kills human monocytes.

  • The immunoproteasome is required to maintain protein turnover in monocytes.

  • Permalink for 'Regulatory T Cells Control PF4/Heparin Antibody Production in Mice [AUTOIMMUNITY]' 19:38

    Regulatory T Cells Control PF4/Heparin Antibody Production in Mice [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Treg cells regulate PF4/heparin-specific Ab production through IL-10.

  • Treg cells are important for the pathogenesis of heparin-induced thrombocytopenia.

  • Permalink for 'Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth [CLINICAL AND HUMAN IMMUNOLOGY]' 19:38

    Fetal T Cell Activation in the Amniotic Cavity during Preterm Labor: A Potential Mechanism for a Subset of Idiopathic Preterm Birth [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Amniotic fluid T cells are of fetal origin and functional in preterm gestations.

  • Amniotic fluid T cells are increased in women with idiopathic preterm labor and birth.

  • Intra-amniotic injection of activated neonatal T cells induces preterm birth in mice.

  • Permalink for 'Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties [IMMUNE REGULATION]' 19:38

    Glycolipid Stimulation of Invariant NKT Cells Expands a Unique Tissue-Resident Population of Precursors to Mature NK Cells Endowed with Oncolytic and Antimetastatic Properties [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • In vivo treatment with α-GalCer results in hepatic pre-mNK cell expansion.

  • α-GalCer–induced pre-mNK cell expansion is mediated by IL-12 and IL-18.

  • α-GalCer–transactivated pre-mNK cells have tumoricidal/antimetastatic activities.

  • Permalink for 'Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 [IMMUNE REGULATION]' 19:38

    Distinct Tissue-Specific Roles for the Disease-Associated Autophagy Genes ATG16L2 and ATG16L1 [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • ATG16L2-deficient mice are viable and exhibit intact canonical autophagy.

  • Intestinal infection reveals ATG16L2–(epithelial) ATG16L1 genetic interaction.

  • Permalink for 'AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes [IMMUNE REGULATION]' 19:38

    AhR Activation Leads to Massive Mobilization of Myeloid-Derived Suppressor Cells with Immunosuppressive Activity through Regulation of CXCR2 and MicroRNA miR-150-5p and miR-543-3p That Target Anti-Inflammatory Genes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • AhR activation leads to induction of MDSCs with immunosuppressive activity.

  • AhR-mediated induction of MDSCs is regulated by microRNA that target CXCR2.

  • Permalink for 'CgCLec-HTM-Mediated Signaling Pathway Regulates Lipopolysaccharide-Induced CgIL-17 and CgTNF Production in Oyster [IMMUNE REGULATION]' 19:38

    CgCLec-HTM-Mediated Signaling Pathway Regulates Lipopolysaccharide-Induced CgIL-17 and CgTNF Production in Oyster [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • CgCLec-HTM was associated with CgSyk to mediate the ERK–Rel pathway.

  • CgERK interacted with CgRel to induce CgRel nuclear translocation.

  • The CgCLec-HTM–mediated pathway induced CgIL-17 and CgTNF production.

  • Permalink for 'Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms [IMMUNE REGULATION]' 19:38

    Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • pM doses of CCL2 are effective in suppressing MOG-induced EAE.

  • The modulation of EAE by CCL2 is associated with downregulation of Th1/Th17 cells.

  • pM levels of CCL2 induce formation of highly functional Tregs.

  • Permalink for 'LSD1 Cooperates with Noncanonical NF-{kappa}B Signaling to Regulate Marginal Zone B Cell Development [IMMUNE SYSTEM DEVELOPMENT]' 19:38

    LSD1 Cooperates with Noncanonical NF-{kappa}B Signaling to Regulate Marginal Zone B Cell Development [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • LSD1 is necessary for marginal zone B cell development.

  • LSD1 represses the follicular B cell and myeloid programs.

  • With noncanonical NF-B, LSD1 regulates marginal zone B cell development.

  • Permalink for 'Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics [IMMUNOGENETICS]' 19:38

    Inferring the "Primordial Immune Complex": Origins of MHC Class I and Antigen Receptors Revealed by Comparative Genomics [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • Emergence of class I/II and Ag receptor genes is proposed via comparative genomics.

  • Nonrearranging Ag receptor–like genes were identified in MHC paralogous regions.

  • Ancient translocation of an MHC genomic region including CD1 genes was discovered and named "MHCtrans."

  • Permalink for 'T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer [INFECTIOUS DISEASE AND HOST RESPONSE]' 19:38

    T Cell- and Monocyte-Specific RNA-Sequencing Analysis in Septic and Nonseptic Critically Ill Patients and in Patients with Cancer [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Sepsis induces transcription of suppressive genes in innate and adaptive immune cells.

  • Sepsis, trauma, and cancer share many common immunosuppressive mechanisms.

  • Monocytic transcriptomic changes during sepsis are markedly suppressive.

  • Permalink for 'Combination of Modified NS1 and NS3 as a Novel Vaccine Strategy against Dengue Virus Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 19:38

    Combination of Modified NS1 and NS3 as a Novel Vaccine Strategy against Dengue Virus Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Active immunization with DJ NS1 plus NS3 induces a strong Ab response.

  • Active immunization with DJ NS1 plus NS3 induces specific T cell responses.

  • Combined DJ NS1 plus NS3 provides enhanced protection against DENV infection.

  • Permalink for 'Uncovering Structural and Molecular Dynamics of ESAT-6:{beta}2M Interaction: Asp53 of Human {beta}2-Microglobulin Is Critical for the ESAT-6:{beta}2M Complexation [INFECTIOUS DISEASE AND HOST RESPONSE]' 19:38

    Uncovering Structural and Molecular Dynamics of ESAT-6:{beta}2M Interaction: Asp53 of Human {beta}2-Microglobulin Is Critical for the ESAT-6:{beta}2M Complexation [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Asp53 residue of β2M is important in forming a complex with Met93 of ESAT-6.

  • SM09 and SM15 rescued ESAT-6–mediated downregulation of MHC class I Ag presentation.

  • SM09 and SM15 inhibited survival of M. tuberculosis inside the macrophage.

  • Permalink for 'IRF7 Is Involved in Both STING and MAVS Mediating IFN-{beta} Signaling in IRF3-Lacking Chickens [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    IRF7 Is Involved in Both STING and MAVS Mediating IFN-{beta} Signaling in IRF3-Lacking Chickens [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • More evidence is provided for the rationale behind the name of chicken IRF7.

  • Chicken IRF7 participates in both MAVS- and STING-mediated IFN-β regulation.

  • Chicken STING mediates the activation of IRF7 through a conserved SLQxSyS motif.

  • Permalink for 'UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6 [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • UBL4A is a novel IFN-stimulated gene.

  • UBL4A positively regulates innate immune response.

  • UBL4A interacts with and targets TRAF6 for K63-linked ubiquitination.

  • Permalink for 'Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    Early Life Represents a Vulnerable Time Window for IL-33-Induced Peripheral Lung Pathology [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • In adults, increased IL-33 expression in the lungs per se is not pathologic.

  • In neonates, increased IL-33 results in severe peripheral lung pathology.

  • Pathologic effects of IL-33 in the lungs are age dependent.

  • Permalink for 'Mesenchymal Stem Cell-Derived Extracellular Vesicles Decrease Lung Injury in Mice [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    Mesenchymal Stem Cell-Derived Extracellular Vesicles Decrease Lung Injury in Mice [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • MSC EV may stimulate increased antimicrobial activity during bacterial pneumonia.

  • Increased antimicrobial activity is associated with increased LTB4 production.

  • MSC EV may increase LTB4 production via transfer of miR145 to target cells.

  • Permalink for 'Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    Increased Complement Factor B and Bb Levels Are Associated with Mortality in Patients with Severe Aortic Stenosis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Plasma FB levels are elevated in patients with symptomatic and asymptomatic AS.

  • High FB and Bb levels are associated with adverse outcome in severe symptomatic AS.

  • FB may be involved in AS pathogenesis and could operate in the early disease phase.

  • Permalink for 'Activation Receptor-Dependent IFN-{gamma} Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome [INNATE IMMUNITY AND INFLAMMATION]' 19:38

    Activation Receptor-Dependent IFN-{gamma} Production by NK Cells Is Controlled by Transcription, Translation, and the Proteasome [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • NK activation receptor–dependent IFN- requires additional signals.

  • Cytokine stimulation, but not activation receptor stimulation, induces Ifng transcription.

  • Activation receptor ligation stimulates IFN- translation through TPL2.

  • Permalink for 'BATF-Interacting Proteins Dictate Specificity in Th Subset Activity [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 19:38

    BATF-Interacting Proteins Dictate Specificity in Th Subset Activity [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Specific Jun family members cooperate with BATF in promoting IL-9 in Th9 cells.

  • Bach2 cooperates with BATF to promote IL-9 in Th9 cells.

  • Expression and function of bZIP factors dictate IL-9 activation in Th17 cells.

  • Permalink for 'Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression [TUMOR IMMUNOLOGY]' 19:38

    Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Many primary human cancers frequently downregulate the transcription factor IRF2.

  • IRF2 loss causes an immune evasion phenotype of low MHC-I and high PD-L1.

  • The MHC-I defect in IRF2-low cells can be restored upon IFN stimulation.

  • Permalink for 'OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function [TUMOR IMMUNOLOGY]' 19:38

    OX40 Agonist Tumor Immunotherapy Does Not Impact Regulatory T Cell Suppressive Function [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Anti-OX40 treatment does not impair TIL Treg suppressive function.

  • OX40 ligation enhances Treg and Tconv proliferation through Tconv cell IL-2 secretion.

  • TIL Tregs proliferate and produce Th1 cytokines after anti-OX40 treatment.

  • Permalink for 'Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth [CORRECTIONS]' 19:38

    Correction: IL-12+IL-18 Cosignaling in Human Macrophages and Lung Epithelial Cells Activates Cathelicidin and Autophagy, Inhibiting Intracellular Mycobacterial Growth [CORRECTIONS]

     » ‎ The Journal of Immunology
  • Permalink for 'Correction: PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5 [CORRECTIONS]' 19:38

    Correction: PRMT1 Plays a Critical Role in Th17 Differentiation by Regulating Reciprocal Recruitment of STAT3 and STAT5 [CORRECTIONS]

     » ‎ The Journal of Immunology
  • Permalink for 'Correction: LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells [CORRECTIONS]' 19:38

    Correction: LILRB1 Blockade Enhances Bispecific T Cell Engager Antibody-Induced Tumor Cell Killing by Effector CD8+ T Cells [CORRECTIONS]

     » ‎ The Journal of Immunology
  • September 09, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway [CUTTING EDGE]' 22:00

    Cutting Edge: Role of MASP-3 in the Physiological Activation of Factor D of the Alternative Complement Pathway [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • MASP-1 is required for physiological LP activation.

  • MASP-3 circulates predominantly in an active form regardless of the role of MASP-1.

  • MASP-3 is pivotal for physiological AP activation via activation of FD.

  • Permalink for 'Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on {alpha}4 Integrins [AUTOIMMUNITY]' 22:00

    Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on {alpha}4 Integrins [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • α4 integrins are dispensable for cDCs and pDCs to populate the CNS in steady-state.

  • Itga4–/– moDCs have a competitive disadvantage to accumulate in the inflamed CNS.

  • Accumulation of CD11b+CD103+ DCs in gut lamina propria is dependent on α4 integrins.

  • Permalink for 'Low Vitamin D Status Is Associated with Epithelial-Mesenchymal Transition in Patients with Chronic Obstructive Pulmonary Disease [AUTOIMMUNITY]' 22:00

    Low Vitamin D Status Is Associated with Epithelial-Mesenchymal Transition in Patients with Chronic Obstructive Pulmonary Disease [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Vitamin D concentrations in COPD patients were lower than concentrations in controls.

  • TGF-β/Smad signaling and EMT were increased in COPD patients compared with controls.

  • Vitamin D status was inversely correlated with EMT in COPD patients.

  • Permalink for 'The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells [IMMUNE REGULATION]' 22:00

    The cAMP-Adenosine Feedback Loop Maintains the Suppressive Function of Regulatory T Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Intracellular cAMP regulates CD39-dependent adenosine production in Tregs.

  • Extracellular cAMP directly participates in Treg-derived adenosine production.

  • Increasing the intracellular cAMP level improves the therapeutic efficacy of iTregs.

  • Permalink for 'TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression [IMMUNE REGULATION]' 22:00

    TNF Receptor-Associated Factor 5 Limits Function of Plasmacytoid Dendritic Cells by Controlling IFN Regulatory Factor 5 Expression [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • TRAF5 deficiency accelerates wound healing by promoting activation of pDCs.

  • TRAF5 controls proinflammatory cytokine production by pDCs via IRF5.

  • Permalink for 'IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    IL-33 Is a Cell-Intrinsic Regulator of Fitness during Early B Cell Development [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • IL-33 is expressed during early B cell development in both mice and humans.

  • Deficiency of IL-33 promotes B cell fitness via a cell-endogenous mechanism.

  • IL-33 expression is modulated in B cell malignancies.

  • Permalink for 'TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human V{gamma}9V{delta}2 T Cells [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    TCR Sequencing Reveals the Distinct Development of Fetal and Adult Human V{gamma}9V{delta}2 T Cells [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Fetal and adult blood V9V2 T cells express a different CDR3 repertoire.

  • The postnatal thymus produces a small number of V9V2 thymocytes.

  • Adult blood V9V2 T cells are derived from postnatal V9V2 thymocytes.

  • Permalink for 'Nasal Vaccination Drives Modifications of Nasal and Systemic Antibody Repertoires in Rainbow Trout [IMMUNOGENETICS]' 22:00

    Nasal Vaccination Drives Modifications of Nasal and Systemic Antibody Repertoires in Rainbow Trout [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • Trout have limited IgM and IgT repertoire diversity in NALT.

  • Intranasal vaccination in trout triggers systemic and mucosal Ig response.

  • IgM and IgT respond to i.p. and intranasal bacterin vaccination.

  • Permalink for 'Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination [IMMUNOGENETICS]' 22:00

    Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination [IMMUNOGENETICS]

     » ‎ The Journal of Immunology
  • HR supports germinal center B cell survival and Ab affinity maturation.

  • HR is active at the hypermutating Ig locus and influences the SHM mutation pattern.

  • The magnitude of A:T mutagenesis during SHM of the Ig V region increases over time.

  • Permalink for 'A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza [IMMUNOTHERAPY AND VACCINES]' 22:00

    A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Human CD4 T cells have limited cross-reactive memory to avian H7 proteins.

  • CD4 T cell help can be provided to B cells with novel H7/H3 chimeric vaccines.

  • Permalink for 'T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • IL-6R signaling on T cells is essential for controlling chronic viral infection.

  • IL-6R signaling on T cells is required for optimal Ab development.

  • IL-6 signaling on T cells regulates ICOS expression on Tfh cells.

  • Permalink for 'c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    c-Abl-Mediated Tyrosine Phosphorylation of PARP1 Is Crucial for Expression of Proinflammatory Genes [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Inflammatory agent exposure causes c-Abl to interact with and phosphorylate PARP1.

  • Tyrosine phosphorylation of PARP1 is crucial for NF-B activation and gene expression.

  • Permalink for 'The BACH1-HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    The BACH1-HMOX1 Regulatory Axis Is Indispensable for Proper Macrophage Subtype Specification and Skeletal Muscle Regeneration [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • BACH1 and myeloid HMOX1 are required for complete muscle regeneration upon acute injury.

  • BACH1–HMOX1 axis is required for coordinated in situ MF phenotype switch.

  • BACH1 regulates inflammatory and repair gene modules in MFs during tissue injury.

  • Permalink for 'A Long Noncoding RNA, Antisense IL-7, Promotes Inflammatory Gene Transcription through Facilitating Histone Acetylation and Switch/Sucrose Nonfermentable Chromatin Remodeling [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    A Long Noncoding RNA, Antisense IL-7, Promotes Inflammatory Gene Transcription through Facilitating Histone Acetylation and Switch/Sucrose Nonfermentable Chromatin Remodeling [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • The transcription of IL-7–AS is dependent on the NF-B/MAPK pathway.

  • IL-7–AS promotes the expression of CCL2, CCL5, CCL7, and IL6.

  • IL-7–AS interacts with p300 and SWI/SNF complex.

  • Permalink for 'YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    YIPF5 Is Essential for Innate Immunity to DNA Virus and Facilitates COPII-Dependent STING Trafficking [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • YIPF5 positively regulates STING-mediated IFN production signaling.

  • YIPF5 is essential for antiviral response against DNA viruses.

  • YIPF5 facilitates STING trafficking by recruiting STING to COPII-coated vesicles.

  • Permalink for 'Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Complement Component C5 and TLR Molecule CD14 Mediate Heme-Induced Thromboinflammation in Human Blood [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Heme induces complement-dependent thromboinflammation in human whole blood.

  • Heme-induced proinflammatory cytokines and tissue factor are C5 dependent.

  • Combined inhibition of C5 and CD14 attenuate prothrombin cleavage.

  • Permalink for 'A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    A Negative Feedback Loop Regulates Integrin Inactivation and Promotes Neutrophil Recruitment to Inflammatory Sites [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • A negative feedback loop, integrin–PI3K–ARAP3–integrin, controls integrin inactivation.

  • Integrin inactivation promotes neutrophil transendothelial migration and recruitment.

  • Permalink for 'Retinoids Enhance the Expression of Cathelicidin Antimicrobial Peptide during Reactive Dermal Adipogenesis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Retinoids Enhance the Expression of Cathelicidin Antimicrobial Peptide during Reactive Dermal Adipogenesis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Retinoids enhance cathelicidin antimicrobial peptide expression during adipogenesis.

  • The action of retinoids is dependent on hypoxia-inducible factor 1-α.

  • The capacity to induce cathelicidin may explain some therapeutic effects of retinoids.

  • Permalink for 'Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Low Cellular NAD+ Compromises Lipopolysaccharide-Induced Inflammatory Responses via Inhibiting TLR4 Signal Transduction in Human Monocytes [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • NAD+ depletion attenuates TLR4 signal transduction in primary human monocytes.

  • The mechanism involves inhibition of protein phosphorylation in the signal cascade.

  • The proteins in the signal pathway are not quantitatively changed by NAD+ depletion.

  • Permalink for 'Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Influenza Vaccination Primes Human Myeloid Cell Cytokine Secretion and NK Cell Function [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Influenza vaccination primes myeloid cells for enhanced cytokine secretion.

  • Vaccine-enhanced myeloid cytokines boost NK cell responses to influenza virus.

  • Permalink for 'Recognition of Class II MHC Peptide Ligands That Contain {beta}-Amino Acids [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Recognition of Class II MHC Peptide Ligands That Contain {beta}-Amino Acids [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Peptides with β-amino acids can bind tightly to MHC-II and activate TCR signaling.

  • Incorporation of β-amino acids enhances resistance to degradation by protease(s).

  • A selected β-amino acid–containing peptide stimulated T cells in mice.

  • Permalink for 'KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behcet Disease [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    KIR3DL1/S1 Allotypes Contribute Differentially to the Development of Behcet Disease [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • KIR3DL1 allotypes impact the development of Behcet disease.

  • This association appears to be independent of the effect of HLA-B*51.

  • Different KIR3DL1 allotypes are associated with mucocutaneous and ophthalmic disease.

  • Permalink for 'TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells [MUCOSAL IMMUNOLOGY]' 22:00

    TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TRIM58 interacts with TLR2, negatively regulating its expression in myeloid cells.

  • Myeloid cell Trim58 deficiency increases susceptibility to acute colitis via Tlr2.

  • Mucosal expression of human TRIM58 is reduced in active ulcerative colitis.

  • Permalink for 'Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients [SYSTEMS IMMUNOLOGY]' 22:00

    Phenotypic and Ig Repertoire Analyses Indicate a Common Origin of IgD-CD27- Double Negative B Cells in Healthy Individuals and Multiple Sclerosis Patients [SYSTEMS IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • DN B cells are abnormally elevated in MS patients but have the same origin as in HC.

  • DN B cells resemble CSM B cells but appear to be at an earlier maturation state.

  • DN and CSM B cells undergo unique differentiation pathways.

  • Permalink for 'EBV Latency III-Transformed B Cells Are Inducers of Conventional and Unconventional Regulatory T Cells in a PD-L1-Dependent Manner [TUMOR IMMUNOLOGY]' 22:00

    EBV Latency III-Transformed B Cells Are Inducers of Conventional and Unconventional Regulatory T Cells in a PD-L1-Dependent Manner [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • EBV latency III B cells display an immunosuppressive profile similar to Bregs.

  • They repress proliferation of T cells and promote expansion of cTregs and uTregs.

  • Expansion of Tregs depends on PD-L1 whose expression depends on the EBV oncogene LMP1.

  • Permalink for 'Correction: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4+ T Cell Activities [CORRECTIONS]' 22:00

    Correction: Bcl2L12 Contributes to Th2-Biased Inflammation in the Intestinal Mucosa by Regulating CD4+ T Cell Activities [CORRECTIONS]

     » ‎ The Journal of Immunology
  • August 19, 2019
  • Permalink for 'In This Issue [IN THIS ISSUE]' 22:00

    In This Issue [IN THIS ISSUE]

     » ‎ The Journal of Immunology
  • Permalink for 'Assembling the Inflammasome, Piece by Piece [PILLARS OF IMMUNOLOGY]' 22:00

    Assembling the Inflammasome, Piece by Piece [PILLARS OF IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer [BRIEF REVIEWS]' 22:00

    Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer [BRIEF REVIEWS]

     » ‎ The Journal of Immunology
  • Permalink for 'Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade [CUTTING EDGE]' 22:00

    Cutting Edge: Targeting Thrombocytes to Rewire Anticancer Immunity in the Tumor Microenvironment and Potentiate Efficacy of PD-1 Blockade [CUTTING EDGE]

     » ‎ The Journal of Immunology
  • Platelets alter frequency, phenotype, and function of tumor-infiltrating lymphocytes.

  • Inhibition of platelet activation improves CD8+ T cell–dependent tumor control.

  • Pretreatment with antiplatelet therapy enhances responsiveness to PD-1 blockade.

  • Permalink for 'The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    The Il9 CNS-25 Regulatory Element Controls Mast Cell and Basophil IL-9 Production [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • The Il9 CNS-25 is required for IL-9 production in mast cells and basophils.

  • There is differential control of the Il9 gene between mast cells and T cells.

  • Intestinal mast cell expansion requires Il9 CNS-25–dependent IL-9.

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