Feeds

17532 items (17532 unread) in 32 feeds

Časopisi Časopisi
Podcast Podcast
Tisak Tisak
Web Web
 «  Expand/Collapse

Časopisi (100 unread)

 
  • Permalink for 'Alternaria B Cell Mimotope Immunotherapy Alleviates Allergic Responses in a Mouse Model [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    Alternaria B Cell Mimotope Immunotherapy Alleviates Allergic Responses in a Mouse Model [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • We screened Alternaria B cell epitopes by the combination of s-IgE and phage.

  • We validated the binding ability of B cell mimotopes in humans and mice in vitro.

  • The B cell mimotope vaccines improved allergic inflammation in a mouse model.

  • Permalink for 'HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    HB-EGF Synthesized by CD4 T Cells Modulates Allergic Airway Eosinophilia by Regulating IL-5 Synthesis [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Intracellular HB-EGF expressed by CD4 T cells increases IL-5 expression by TH2 cells.

  • HB-EGF in CD4 T cells regulates IL-5 synthesis by inhibiting Bcl-6.

  • Permalink for 'Nanoparticles Containing an Insulin-ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells [AUTOIMMUNITY]' 22:00

    Nanoparticles Containing an Insulin-ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • A hybrid insulin peptide (HIP) neoepitope can tolerize diabetogenic T cells.

  • Tolerance induction promotes T cell anergy and increases Treg/Teff ratio.

  • HIPs are potential therapeutics in type 1 diabetes.

  • Permalink for 'Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus [AUTOIMMUNITY]' 22:00

    Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CD40 antagonism reverses severe proteinuria and restores glomerular morphology.

  • CD40 antagonism normalizes nephrotic and injury-associated gene expression.

  • CD40 antagonism disrupts multiple disease-critical immunological mechanisms.

  • Permalink for 'A Deficit of CEACAM-1-Expressing T Lymphocytes Supports Inflammation in Primary Progressive Multiple Sclerosis [AUTOIMMUNITY]' 22:00

    A Deficit of CEACAM-1-Expressing T Lymphocytes Supports Inflammation in Primary Progressive Multiple Sclerosis [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • CEACAM-1/TIM-3 interaction favors the apoptosis of MBP-specific cells in BEMS.

  • This pathway is reduced in PPMS by the upregulation of Bat3.

  • Permalink for 'Widespread Tau-Specific CD4 T Cell Reactivity in the General Population [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Widespread Tau-Specific CD4 T Cell Reactivity in the General Population [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Permalink for 'CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • PP2A readily promotes IL-2R signaling in Tregs but not T effector cells.

  • PP2A enhances IL-2R signaling in Tregs by CD25-dependent and -independent mechanisms.

  • PP2A broadly regulates the stability, activation, and function of human Tregs.

  • Permalink for 'Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism [IMMUNE REGULATION]' 22:00

    Protease-Activated Receptor 1 Deletion Causes Enhanced Osteoclastogenesis in Response to Inflammatory Signals through a Notch2-Dependent Mechanism [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • PAR1 is transiently expressed in osteoclast precursor cells during differentiation.

  • PAR1 deletion enhances osteoclastogenesis, whereas PAR1 overexpression inhibits it.

  • The enhanced osteoclastogenesis of PAR1-deletion is mediated by Notch2.

  • Permalink for 'The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection [IMMUNE REGULATION]' 22:00

    The Lysophosphatidylcholine Transporter MFSD2A Is Essential for CD8+ Memory T Cell Maintenance and Secondary Response to Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • MFSD2A is required for CD8+ memory T cell maintenance.

  • MFSD2A deficiency results in defective import of LPC species into CD8+ T cells.

  • Import of LPC helps to maintain memory T cell homeostasis.

  • Permalink for 'Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis [IMMUNE REGULATION]' 22:00

    Metformin Augments Anti-Inflammatory and Chondroprotective Properties of Mesenchymal Stem Cells in Experimental Osteoarthritis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Metformin enhances immunomodulatory properties and migration capacity of MSCs.

  • Metformin-treated MSCs exert therapeutic property in OA rats.

  • Permalink for 'Effects of PI3K Inhibition on Afucosylated Antibody-Driven Fc{gamma}RIIIa Events and Phospho-S6 Activity in NK Cells [IMMUNE REGULATION]' 22:00

    Effects of PI3K Inhibition on Afucosylated Antibody-Driven Fc{gamma}RIIIa Events and Phospho-S6 Activity in NK Cells [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Afucosylated Abs offset PI3K inhibitors to retain effective signaling and function.

  • Phosphorylation of S6 is temporally driven by PI3K.

  • p-S6 temporally regulates late cytokine production by modulating transcription.

  • Permalink for 'The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function [IMMUNE REGULATION]' 22:00

    The Cross-Talk between miR-511-3p and C-Type Lectin Receptors on Dendritic Cells Affects Dendritic Cell Function [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • The miR-511-3p regulates MR and DC-SIGN expression in human DCs.

  • Silencing miR-511-3p expression promotes anti-inflammatory DC phenotype.

  • Changes in miR-511-3p levels in DCs affect T cell polarization in DC–T coculture.

  • Permalink for 'Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes [IMMUNE REGULATION]' 22:00

    Regulation of Diabetogenic Immunity by IL-15-Activated Regulatory CD8 T Cells in Type 1 Diabetes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • NOD mice are deficient in number and function of CD8 Tregs that control the germinal center.

  • Treatment with IL-15 superagonist expands NOD CD8 Tregs and restores their activity.

  • IL-15–activated CD8 Tregs delay the adoptive transfer of type 1 diabetes.

  • Permalink for 'Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Thymic Development of a Unique Bone Marrow-Resident Innate-like T Cell Subset with a Potent Innate Immune Function [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • BMDNT cells are developed by default of thymic TCR-mediated selection.

  • BMDNT cells show the features of ILCs bearing many NK receptors.

  • BMDNT cells are rapidly increased and activated in response to systemic TLR ligands.

  • Permalink for 'Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Phosphorylation at S2053 in Murine (S2056 in Human) DNA-PKcs Is Dispensable for Lymphocyte Development and Class Switch Recombination [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • Radiation induces S2053 phosphorylation of murine DNA-PKcs.

  • S2053 phosphorylation is dispensable for V(D)J and class switch recombination.

  • Permalink for 'SOCS1 Antagonist-Expressing Recombinant Bacillus Calmette-Guerin Enhances Antituberculosis Protection in a Mouse Model [IMMUNOTHERAPY AND VACCINES]' 22:00

    SOCS1 Antagonist-Expressing Recombinant Bacillus Calmette-Guerin Enhances Antituberculosis Protection in a Mouse Model [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • rBCG-SOCS1DN enhanced the induction of Ag-specific T cells via the activation of DC.

  • Ag-specific T cell enhancement enhanced protection against M. tuberculosis infection.

  • Permalink for 'Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma [IMMUNOTHERAPY AND VACCINES]' 22:00

    Armored Inducible Expression of IL-12 Enhances Antitumor Activity of Glypican-3-Targeted Chimeric Antigen Receptor-Engineered T Cells in Hepatocellular Carcinoma [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Inducibly expressed IL-12–armored GPC3-specific CARs were constructed in this study.

  • GPC3-28Z-NFAT-IL-12 T cells could lyse GPC3+ tumor cells specifically in vitro.

  • GPC3-28Z-NFAT-IL-12 T cells could enhance antitumor activity in vivo.

  • Permalink for 'T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Gastric PC acquire high rates of somatic hypermutations during H. pylori infection.

  • Gastric poly- and H. pylori–specific Ig evolve from Ag-driven and T cell–dependent responses.

  • VH genes of H. pylori–specific Ig resemble MALT B cell lymphoma Ig genes.

  • Permalink for 'Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Carp macrophages exhibit a trained immunity-like profile in vitro.

  • Both peptidoglycan and β-glucan can induce trained immunity in carp macrophages.

  • Permalink for 'C-Reactive Protein Promotes Inflammation through Fc{gamma}R-Induced Glycolytic Reprogramming of Human Macrophages [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    C-Reactive Protein Promotes Inflammation through Fc{gamma}R-Induced Glycolytic Reprogramming of Human Macrophages [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Under inflammatory conditions, CRP is not only a marker but also a driver of inflammation by human macrophages.

  • CRP enhances inflammatory cytokine production via FcR-induced metabolic reprogramming through kinases Syk, PI3K, and AKT2.

  • Permalink for 'Inflammasome-Independent and Atypical Processing of IL-1{beta} Contributes to Acid Aspiration-Induced Acute Lung Injury [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Inflammasome-Independent and Atypical Processing of IL-1{beta} Contributes to Acid Aspiration-Induced Acute Lung Injury [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Inflammasome-independent IL-1β production contributes to aspiration pneumonitis.

  • Acidic stress induces the production of mature IL-1β in macrophages.

  • A novel cleavage site of IL-1β in response to acidic stress was identified.

  • Permalink for 'Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Macrophages Guard Endothelial Lineage by Hindering Endothelial-to-Mesenchymal Transition: Implications for the Pathogenesis of Systemic Sclerosis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Lung endothelial precursor cells are committed to EndoMT during experimental fibrosis.

  • Signals in the sera of patients with systemic sclerosis reproduce EndoMT in vitro.

  • Macrophages protect from both EndoMT induction and experimental fibrosis.

  • Permalink for 'USP19 Inhibits TNF-{alpha}- and IL-1{beta}-Triggered NF-{kappa}B Activation by Deubiquitinating TAK1 [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    USP19 Inhibits TNF-{alpha}- and IL-1{beta}-Triggered NF-{kappa}B Activation by Deubiquitinating TAK1 [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • USP19 negatively regulates TAK1-mediated NF-B activation.

  • Usp19 deficiency promotes TNF-α– and IL-1β–induced inflammatory response.

  • USP19 removes K63- and K27-linked polyubiquitin chains from TAK1.

  • Permalink for 'CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    CUL7 E3 Ubiquitin Ligase Mediates the Degradation of Activation-Induced Cytidine Deaminase and Regulates the Ig Class Switch Recombination in B Lymphocytes [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CUL7-FBXW11 E3 ligase mediates the ubiquitination and degradation of AID.

  • DNA damage response promotes CUL7–FBXW11–AID interaction.

  • Knockout of CUL7 promotes IgA and IgG1 class switch recombination of B cells.

  • Permalink for 'Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43 [MUCOSAL IMMUNOLOGY]' 22:00

    Microbiota Metabolite Short-Chain Fatty Acids Facilitate Mucosal Adjuvant Activity of Cholera Toxin through GPR43 [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Depletion of gut microbiota decreases the adjuvant activity of CT.

  • Gut microbiota-derived SCFAs facilitate mucosal adjuvant activity of CT via GPR43.

  • SCFA induction of BAFF and ALDH1a2 in DC promotes B cell Ab production.

  • Permalink for 'Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses [CORRECTIONS]' 22:00

    Correction: CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses [CORRECTIONS]

     » ‎ The Journal of Immunology
  •  
    Podcast →