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  • Permalink for 'The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Pglyrp1 enhances allergic asthma in mice through its effect on the intestinal microbiome.

  • This effect is strong in asthma-prone mice and weak in asthma-resistant outbred mice.

  • This effect requires germ-free mice before colonization with the Pglyrp1 microbiome.

  • Permalink for 'Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • IgG fucosylation status and target cell Ag density determine NK cell ADCC.

  • Aspecific serum IgG bound to FcRIIIa and target cell glycocalyx limit NK cell ADCC.

  • NK cell FcRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.

  • Permalink for 'Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]' 22:00

    Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Anti-C3d mAb 3d-8b blocks in vivo CR2-dependent Ab production to foreign Ags.

  • Anti-C3d mAb 3d-8b is capable of blocking in vivo iC3b/C3d from CR1/CR2.

  • Disruption of the B cell–CR2 costimulatory signal reduces autoantibody production.

  • Permalink for 'TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TNF-producing CD4+ T cells in patients with AIH are significantly expanded.

  • Most TNF-producing T cells also produce IFN- and have an inflammatory phenotype.

  • Autoantigen-specific stimulation results in expansion of these inflammatory T cells.

  • Permalink for 'CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Chemokine ligand CCL2 is cleared from the blood in a CCR2-dependent manner.

  • CCR2-dependent clearance of CCL2 is G protein (Gαi, Gαs, or Gαq/11) independent.

  • Equilibrium between secretion of CCL2 and its uptake by CCL2 determines blood levels.

  • Permalink for 'Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CRISPR gene disruption in CD4+ T cells is enhanced by donor DNA template delivery.

  • Disruption of key signaling proteins in human CD4+ T cells mimics murine data.

  • Hyperactive signaling in human T cells can drive compensatory regulatory responses.

  • Permalink for 'CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CXCR3 identifies human naive CD8+ T cells with biased effector potential.

  • Human naive CD8+ T cell subsets are functionally and transcriptionally distinct.

  • Effector potential correlates with the physicochemical attributes of expressed TCRs.

  • Permalink for 'Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Circulating intermediate monocytes are enriched in AH patients.

  • AH intermediate monocytes are functionally activated.

  • AH intermediate monocytes induce CD4+ T cell IL-17 and are enriched in the liver.

  • Permalink for 'Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]' 22:00

    Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • A high-fiber diet attenuates arthritis in a microbiota-dependent manner.

  • Butyrate attenuates arthritis in an iNKT cell–dependent manner.

  • Butyrate inhibits cytokine production of iNKT cells in an HDAC-dependent manner.

  • Permalink for 'The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]' 22:00

    The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RORα deficiency leads to a reduction in ILC2 and ILC3 subsets during infection.

  • Residual Rorasg/sg ILC3s have lower expression of Rorc and lineage-specific receptors.

  • RORα conserves ILC3 function by modulating integration of environmental cues.

  • Permalink for 'CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]' 22:00

    CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • FcR activation in human monocytes regulates the localization and expression of CD31.

  • FcR-mediated CD31 downregulation is mediated mainly through FcRIIa and PI3K.

  • CD31 negatively regulates FcR-mediated phagocytosis but not cytokine production.

  • Permalink for 'OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]' 22:00

    OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • OX40L-JAG1 induced Treg proliferation mediated via noncanonical NF-B signaling.

  • OX40L-JAG1 expanded epigenetically stable and suppressive Tregs to ameliorate EAT.

  • OX40L-JAG1 induced TCR-independent selective proliferation of human thymic Tregs.

  • Permalink for 'Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]' 22:00

    Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Western diet feeding increases Nrp1 on Foxp3 CD4 T cells in ApoE–/– mice.

  • Nrp1+Foxp3 CD4 T cells are highly proliferative and atherogenic.

  • Nrp1+Foxp3 CD4 T cells preferentially migrate to the aorta and PaLN.

  • Permalink for 'Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype [IMMUNE REGULATION]' 22:00

    Adenosine Receptor Signaling Targets Both PKA and Epac Pathways to Polarize Dendritic Cells to a Suppressive Phenotype [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Adenosine targets both PKA and Epac pathways to suppress dendritic cell activation.

  • Adenosine/cAMP increases the expression of negative regulators of NF-B signaling.

  • Permalink for 'miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    miR-183-96-182 Cluster Is Involved in Invariant NKT Cell Development, Maturation, and Effector Function [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • miR-183C expression dynamically changes during iNKT cell development.

  • The deletion of miR-183C interferes with iNKT cell development and function.

  • Multiple target molecules are involved in miR-183C–mediated iNKT cell regulation.

  • Permalink for 'Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5 [IMMUNE SYSTEM DEVELOPMENT]' 22:00

    Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5 [IMMUNE SYSTEM DEVELOPMENT]

     » ‎ The Journal of Immunology
  • 2F5 BCR B cells are tolerized primarily by reactivity to kynureninase, not lipid.

  • Extensive receptor editing occurs in 2F5 BCR knock-in mice.

  • Mature and anergic B cells often express identical BCRs in 2F5 knock-in mice.

  • Permalink for 'Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses [IMMUNOTHERAPY AND VACCINES]' 22:00

    Immune-Focusing Properties of Virus-like Particles Improve Protective IgA Responses [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • VLP enhances antinorovirus IgA recall responses in humanized mice.

  • Particulate structure is required for IgA enhancement.

  • VLP-driven IgA responses are functionally superior to IgG responses.

  • Permalink for 'Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 [IMMUNOTHERAPY AND VACCINES]' 22:00

    Early Protection against Pertussis Induced by Live Attenuated Bordetella pertussis BPZE1 Depends on TLR4 [IMMUNOTHERAPY AND VACCINES]

     » ‎ The Journal of Immunology
  • Live pertussis vaccine BPZE1 protects against B. pertussis infection within days.

  • Early protection induced by BPZE1 does not depend on adaptive immune responses.

  • Early protection induced by BPZE1 depends on TLR4-mediated innate immune responses.

  • Permalink for 'Pathogenic Role of an IL-23/{gamma}{delta}T17/Neutrophil Axis in Coxsackievirus B3-Induced Pancreatitis [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Pathogenic Role of an IL-23/{gamma}{delta}T17/Neutrophil Axis in Coxsackievirus B3-Induced Pancreatitis [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • CVB3 infection induces a transient IL-17A expression in the pancreas of mice.

  • Pancreatic IL-17A is mainly produced by V4 T cells.

  • IL-23/T17/neutrophil axis is critically involved in the onset of CVB3 pancreatitis.

  • Permalink for 'Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections [INFECTIOUS DISEASE AND HOST RESPONSE]' 22:00

    Chronic Ethanol Consumption Reduces Existing CD8 T Cell Memory and Is Associated with Lesions in Protection against Secondary Influenza A Virus Infections [INFECTIOUS DISEASE AND HOST RESPONSE]

     » ‎ The Journal of Immunology
  • Chronic EtOH consumption alters the existing memory T cell compartment.

  • EtOH-induced changes in existing memory T cells increase susceptibility to IAV.

  • Chronic EtOH alters memory T cell–mediated killing and recruitment into the lungs.

  • Permalink for 'STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • An IBD genetic risk variant increases expression of both STAT3 and STAT5 in MDMs.

  • Inflammatory cytokines increase once STAT3/STAT5 expression falls below a threshold.

  • Various STAT3/STAT5-dependent inhibitory cytokines cooperate to reduce inflammation.

  • Permalink for 'Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Regulatory Role for NK Cells in a Mouse Model of Systemic Juvenile Idiopathic Arthritis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • Mice with sJIA show aberrant NK cell phenotype and defective NK cell cytotoxicity.

  • NK cells have a regulatory role in the development of sJIA disease.

  • NK cell defects are associated with more activated monocytes and dendritic cells.

  • Permalink for 'Staphylococcus aureus-Derived PSM{alpha} Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate {beta}-Arrestin Recruitment and Chemotaxis [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Staphylococcus aureus-Derived PSM{alpha} Peptides Activate Neutrophil FPR2 but Lack the Ability to Mediate {beta}-Arrestin Recruitment and Chemotaxis [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • FPR2-specific PSMα peptides are not chemotactic but activate the NADPH oxidase.

  • PSMα peptides induce ERK1/2 phosphorylation but not β-arrestin recruitment.

  • Permalink for 'IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • We established an exhaustive list of larval zebrafish ISGs.

  • Orthologous ISGs in fish and humans identify a large ancestral ISG repertoire.

  • Permalink for 'Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-{beta} [INNATE IMMUNITY AND INFLAMMATION]' 22:00

    Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-{beta} [INNATE IMMUNITY AND INFLAMMATION]

     » ‎ The Journal of Immunology
  • The cleavage determinants of duSTING by NS2B3 are the R84 and G85 residues.

  • The interaction region is essential for the cleavage of duSTING by NS2B3.

  • Permalink for 'Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    Structural and Functional Basis for LILRB Immune Checkpoint Receptor Recognition of HLA-G Isoforms [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • The β2m-free HLA-G1 isoform tends to dimerize and further multimerize.

  • The β2m-free HLA-G1 isoform specifically binds to LILRB2 with avidity effects.

  • The crystal structure of LILRB1/HLA-G1 complex showed a flexible binding manner.

  • Permalink for 'A TCR {beta}-Chain Motif Biases toward Recognition of Human CD1 Proteins [MOLECULAR AND STRUCTURAL IMMUNOLOGY]' 22:00

    A TCR {beta}-Chain Motif Biases toward Recognition of Human CD1 Proteins [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TCR β variable gene 4-1 (TRBV4-1) is overrepresented among CD1b-specific T cells.

  • The association between TRBV4-1 usage and CD1b is independent of lipid Ag.

  • CD1b residue E80 is essential for binding of TRBV4-1–utilizing TCRs.

  • Permalink for 'Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells [MUCOSAL IMMUNOLOGY]' 22:00

    Activation of NLRX1 by NX-13 Alleviates Inflammatory Bowel Disease through Immunometabolic Mechanisms in CD4+ T Cells [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • NLRX1 activation induces immunometabolic mechanisms to reduce effector CD4+ T cells.

  • NX-13 is a novel NLRX1-targeting therapeutic for IBD.

  • NX-13 is effective in three mouse models of IBD and primary human cells from UC.

  • Permalink for 'Macrophages Are a Potent Source of Streptococcus-Induced IFN-{beta} [MUCOSAL IMMUNOLOGY]' 22:00

    Macrophages Are a Potent Source of Streptococcus-Induced IFN-{beta} [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Bone marrow GM-CSF culture gives rise to four distinct populations.

  • GM-CSF M can produce IFN-β.

  • GBS-stimulated GM-CSF M have the ability to adapt their phenotype to be more DC like.

  • Permalink for 'Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis [MUCOSAL IMMUNOLOGY]' 22:00

    Obesity Modulates Intestinal Intraepithelial T Cell Persistence, CD103 and CCR9 Expression, and Outcome in Dextran Sulfate Sodium-Induced Colitis [MUCOSAL IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Diet-induced obese mice exhibit reduced αβ and IEL persistence within 7 wk.

  • Obese mice are more susceptible to dextran sulfate sodium–induced colitis.

  • Diet-induced weight loss restores IEL number and improves outcome in colitis.

  • Permalink for 'A Novel Immunosuppressant, Luteolin, Modulates Alloimmunity and Suppresses Murine Allograft Rejection [TRANSPLANTATION]' 22:00

    A Novel Immunosuppressant, Luteolin, Modulates Alloimmunity and Suppresses Murine Allograft Rejection [TRANSPLANTATION]

     » ‎ The Journal of Immunology
  • Luteolin suppresses allograft rejection by regulating alloimmune responses.

  • Luteolin reduces effector T cell frequency while inducing CD4+Foxp3+ Tregs.

  • It also inhibits T cell proliferation by downregulating AKT/mTOR signaling.

  • Permalink for 'Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer [TUMOR IMMUNOLOGY]' 22:00

    Exosomes Produced by Mesenchymal Stem Cells Drive Differentiation of Myeloid Cells into Immunosuppressive M2-Polarized Macrophages in Breast Cancer [TUMOR IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Breast tumor MSC-derived exosomes elicit differentiation of M-MDSC to TAM.

  • MSC exosome–educated myeloid cells exacerbate immunosuppression in the breast TME.

  • In vivo PD-L1 blockade neutralizes MSC exosome–driven breast cancer progression.

  • Permalink for 'Correction: T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [CORRECTIONS]' 22:00

    Correction: T Cell-Dependent Maturation of Pathogen-Specific Igs in the Antrum of Chronically Helicobacter pylori-Infected Patients [CORRECTIONS]

     » ‎ The Journal of Immunology
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