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  • Permalink for 'The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]' 22:00

    The Pglyrp1-Regulated Microbiome Enhances Experimental Allergic Asthma [ALLERGY AND OTHER HYPERSENSITIVITIES]

     » ‎ The Journal of Immunology
  • Pglyrp1 enhances allergic asthma in mice through its effect on the intestinal microbiome.

  • This effect is strong in asthma-prone mice and weak in asthma-resistant outbred mice.

  • This effect requires germ-free mice before colonization with the Pglyrp1 microbiome.

  • Permalink for 'Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]' 22:00

    Functional Attributes of Antibodies, Effector Cells, and Target Cells Affecting NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity [ANTIGEN RECOGNITION AND RESPONSES]

     » ‎ The Journal of Immunology
  • IgG fucosylation status and target cell Ag density determine NK cell ADCC.

  • Aspecific serum IgG bound to FcRIIIa and target cell glycocalyx limit NK cell ADCC.

  • NK cell FcRIIIa is preferentially occupied by high-affinity afucosylated serum IgG.

  • Permalink for 'Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]' 22:00

    Targeting the Immune Complex-Bound Complement C3d Ligand as a Novel Therapy for Lupus [AUTOIMMUNITY]

     » ‎ The Journal of Immunology
  • Anti-C3d mAb 3d-8b blocks in vivo CR2-dependent Ab production to foreign Ags.

  • Anti-C3d mAb 3d-8b is capable of blocking in vivo iC3b/C3d from CR1/CR2.

  • Disruption of the B cell–CR2 costimulatory signal reduces autoantibody production.

  • Permalink for 'TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    TNF-Producing Th1 Cells Are Selectively Expanded in Liver Infiltrates of Patients with Autoimmune Hepatitis [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • TNF-producing CD4+ T cells in patients with AIH are significantly expanded.

  • Most TNF-producing T cells also produce IFN- and have an inflammatory phenotype.

  • Autoantigen-specific stimulation results in expansion of these inflammatory T cells.

  • Permalink for 'CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Chemokine ligand CCL2 is cleared from the blood in a CCR2-dependent manner.

  • CCR2-dependent clearance of CCL2 is G protein (Gαi, Gαs, or Gαq/11) independent.

  • Equilibrium between secretion of CCL2 and its uptake by CCL2 determines blood levels.

  • Permalink for 'Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CRISPR gene disruption in CD4+ T cells is enhanced by donor DNA template delivery.

  • Disruption of key signaling proteins in human CD4+ T cells mimics murine data.

  • Hyperactive signaling in human T cells can drive compensatory regulatory responses.

  • Permalink for 'CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    CXCR3 Identifies Human Naive CD8+ T Cells with Enhanced Effector Differentiation Potential [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • CXCR3 identifies human naive CD8+ T cells with biased effector potential.

  • Human naive CD8+ T cell subsets are functionally and transcriptionally distinct.

  • Effector potential correlates with the physicochemical attributes of expressed TCRs.

  • Permalink for 'Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]' 22:00

    Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+ T Cells [CLINICAL AND HUMAN IMMUNOLOGY]

     » ‎ The Journal of Immunology
  • Circulating intermediate monocytes are enriched in AH patients.

  • AH intermediate monocytes are functionally activated.

  • AH intermediate monocytes induce CD4+ T cell IL-17 and are enriched in the liver.

  • Permalink for 'Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]' 22:00

    Invariant NKT Cells Functionally Link Microbiota-Induced Butyrate Production and Joint Inflammation [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • A high-fiber diet attenuates arthritis in a microbiota-dependent manner.

  • Butyrate attenuates arthritis in an iNKT cell–dependent manner.

  • Butyrate inhibits cytokine production of iNKT cells in an HDAC-dependent manner.

  • Permalink for 'The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]' 22:00

    The Transcription Factor ROR{alpha} Preserves ILC3 Lineage Identity and Function during Chronic Intestinal Infection [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • RORα deficiency leads to a reduction in ILC2 and ILC3 subsets during infection.

  • Residual Rorasg/sg ILC3s have lower expression of Rorc and lineage-specific receptors.

  • RORα conserves ILC3 function by modulating integration of environmental cues.

  • Permalink for 'CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]' 22:00

    CD31 Acts as a Checkpoint Molecule and Is Modulated by Fc{gamma}R-Mediated Signaling in Monocytes [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • FcR activation in human monocytes regulates the localization and expression of CD31.

  • FcR-mediated CD31 downregulation is mediated mainly through FcRIIa and PI3K.

  • CD31 negatively regulates FcR-mediated phagocytosis but not cytokine production.

  • Permalink for 'OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]' 22:00

    OX40L-JAG1-Induced Expansion of Lineage-Stable Regulatory T Cells Involves Noncanonical NF-{kappa}B Signaling [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • OX40L-JAG1 induced Treg proliferation mediated via noncanonical NF-B signaling.

  • OX40L-JAG1 expanded epigenetically stable and suppressive Tregs to ameliorate EAT.

  • OX40L-JAG1 induced TCR-independent selective proliferation of human thymic Tregs.

  • Permalink for 'Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]' 22:00

    Neuropilin-1 Expression on CD4 T Cells Is Atherogenic and Facilitates T Cell Migration to the Aorta in Atherosclerosis [IMMUNE REGULATION]

     » ‎ The Journal of Immunology
  • Western diet feeding increases Nrp1 on Foxp3 CD4 T cells in ApoE–/– mice.

  • Nrp1+Foxp3 CD4 T cells are highly proliferative and atherogenic.

  • Nrp1+Foxp3 CD4 T cells preferentially migrate to the aorta and PaLN.

  •